2. Metabolic Enzyme/Protease
  3. MMP
  4. FN-439 TFA

FN-439 TFA is a selective collagenase-1 inhibitor. FN-439 TFA inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 TFA can be used for the research of cancer and inflammation.

For research use only. We do not sell to patients.

FN-439 TFA Chemical Structure

FN-439 TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 270 In-stock
10 mg USD 420 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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FN-439 TFA Related Antibodies

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Description

FN-439 TFA is a selective collagenase-1 inhibitor. FN-439 TFA inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 TFA can be used for the research of cancer and inflammation[1][2].

Molecular Weight

604.58

Formula

C25H35F3N6O8
Appearance

Solid

Color

White to off-white

SMILES

OC(C(F)(F)F)=O.ONC([C@@H](C)NC([C@@H](CC(C)C)NC([C@H]1N(CCC1)C(CNC(C2=CC=C(C=C2)N)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (413.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6540 mL 8.2702 mL 16.5404 mL
5 mM 0.3308 mL 1.6540 mL 3.3081 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6540 mL 8.2702 mL 16.5404 mL 41.3510 mL
5 mM 0.3308 mL 1.6540 mL 3.3081 mL 8.2702 mL
10 mM 0.1654 mL 0.8270 mL 1.6540 mL 4.1351 mL
15 mM 0.1103 mL 0.5513 mL 1.1027 mL 2.7567 mL
20 mM 0.0827 mL 0.4135 mL 0.8270 mL 2.0676 mL
25 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.6540 mL
30 mM 0.0551 mL 0.2757 mL 0.5513 mL 1.3784 mL
40 mM 0.0414 mL 0.2068 mL 0.4135 mL 1.0338 mL
50 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8270 mL
60 mM 0.0276 mL 0.1378 mL 0.2757 mL 0.6892 mL
80 mM 0.0207 mL 0.1034 mL 0.2068 mL 0.5169 mL
100 mM 0.0165 mL 0.0827 mL 0.1654 mL 0.4135 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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FN-439 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FN-439FN439FN 439MMPMatrix metalloproteinasescollagenase-1cancerinflammationapical periodontitiscollagenaseInhibitorinhibitorinhibit

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