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Antiplasmodial activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Akt (1) Aminopeptidase (1) AMPK (1) Antibiotic (1) Apoptosis (4) Bacterial (11) Caspase (1) Cholinesterase (ChE) (5) COX (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Endogenous Metabolite (2) Ephrin Receptor (1) Farnesyl Transferase (1) Fungal (2) GSK-3 (1) HDAC (1) Herbicide (2) HIF/HIF Prolyl-Hydroxylase (1) Insecticide (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Lactate Dehydrogenase (1) Monoamine Oxidase (1) mTOR (2) NF-κB (4) Nucleoside Antimetabolite/Analog (1) p38 MAPK (1) Parasite (59) Photosystem II (2) PI4K (1) PKG (1) PROTAC Linkers (1) Reference Standards (2) Topoisomerase (2) β-catenin (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (2) Endocrinology (2) Infection (62) Inflammation/Immunology (11) Metabolic Disease (2) Neurological Disease (5)
Click Chemistry:	PROTAC Synthesis (1) Alkynes (1)

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Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-N0740

Jatrorrhizine chloride 3 Publications Verification	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine chloride is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of?AChE?(IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N0749

Jatrorrhizine	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease
Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N1581

Quassin Nigakilactone D	Parasite	Infection Endocrinology
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits *P. falciparum* with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-N0749A

Jatrorrhizine hydroxide 3 Publications Verification	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N5109

Cheilanthifoline	Parasite	Infection
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC₅₀s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .

HY-N6009

8-Deoxygartanin	Parasite NF-κB	Infection
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM .

HY-N8349

19,20-Epoxycytochalasin D	Parasite Endogenous Metabolite	Infection Cancer
19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-N6251

Cratoxylone	Parasite	Infection
Cratoxylone, isolated from the bark of Cratoxylum Cochinchinense, possesses antiplasmodial activity .

HY-E70250

Neocryptolepine Cryptotackieine	Parasite Bacterial Fungal	Infection
Neocryptolepine (Cryptotackieine) has antiplasmodial activity. Neocryptolepine also shows antibacterial activity against Gram-positive bacteria (MIC < 100 μg/mL), and antifungal activity .

HY-N5005

Guanfu base H Atisinium chloride	Parasite	Infection
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial *Plasmodium falciparum* strains TM4/8.2 (wild type) and K1CB1 with IC₅₀ values of 4 μM and 3.6 μM, respectively .

HY-N9343

Kulactone	Bacterial Fungal Parasite	Infection Inflammation/Immunology
Kulactone, a natural bioflavonoid and an inhibitor against jRdRp, possesses antifungal, antibacterial and antiplasmodial activities. Kulactone exhibit no crossing through Blood Brain Barrier (BBB) .

HY-N4037

Homopterocarpin (-)-Homopterocarpin; 3,9-Dimethoxypterocarpan	Monoamine Oxidase Parasite	Inflammation/Immunology
Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective, antioxidant and antiplasmodial activity. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC₅₀ and a K_i of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress .

HY-N7985

Pendulone	Parasite Bacterial	Infection Cancer
Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC₅₀ of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity .

HY-N4307

Laetanine	Parasite	Infection
Laetanine is a noraporphine alkaloid from Litsea laeta, exhibits antiplasmodial activity. Laetanine can be found in the extract of the leaves of Phoebe tavoyana (Meissn) Hook .

HY-N11031

Z-Antiepilepsirine	Parasite	Infection
Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC₅₀ value of 27 µM for W2 strain of Plasmodium falciparum .

HY-N15748

Pelorol (-)-Pelorol	Parasite	Infection
Pelorol ((-)-Pelorol) is a sesquiterpene found in the tropical marine sponge Dactylospongia elegans. Pelorol has weak antitrypanosomal activity with an IC₅₀ of 17.4 μg/mL and antiplasmodial activity against Plasmodium falciparum clones K1 and NF54 with IC₅₀ values of 786 ng/mL and 1911 ng/mL, respectively. Pelorol is promising for research of parasitic diseases, such as trypanosomiasis and malaria .

HY-N2891

Aristolactam A II Aristololactam A II	Parasite COX	Infection
Aristolactam A II (Aristololactam A II) is a weak COX inhibitor with cytotoxic and anti-plasmodial activities. Aristolactam A II exhibits inhibitory activity against Chloroquine (HY-17589A)-sensitive strains, and exerts its inhibitory effect on Plasmodium falciparum growth by inducing cell membrane damage marked by LDH release. Aristolactam A II can be applied to the research of malaria-related mechanisms .

HY-N3378

Lipiferolide	Farnesyl Transferase Parasite	Infection
Lipiferolide is an antiplasmodial agent (IC₅₀: 1.8 μg/mL) that can be isolated from Liriodendron tulipifera. Lipiferolide also inhibits FPTase, and has antitumor activity .

HY-N1219

Stephanine (-)-Stephanine; l-Stephanine	Apoptosis Parasite	Infection Inflammation/Immunology Cancer
Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid. Stephanine induce apoptosis through the reverse of mitotic exit. Stephanine exhibits Antiplasmodial activity. Stephanine can be used for the research of stomach pain, abdominal pain, arthritis and cancer .

HY-N2932

β-Yohimbine Amsonin; Amsonine; NSC 93133	Parasite	Infection
β-Yohimbine (Amsonin) is an indole alkaloid that can be isolated from Aspidosperma ulei Markgr. β-Yohimbine shows antiplasmodial activity against the Chloroquine (HY-17589A)-resistant Fc M29-Cameroon strain (IC₅₀: > 1 μg/mL) .

HY-147971

Anticancer agent 75	Parasite Topoisomerase	Infection Cancer
Anticancer agent 75 is a potent anticancer agent. Anticancer agent 75 shows cytotoxicity and selectivity in cancer cell lines. Anticancer agent 75 shows cytotoxicity to normal human kidney cell lines is at least 35 times lower than that of the Doxorubicin standard. Anticancer agent 75 shows good activity of antiplasmodial .

HY-112728

MMV024101	Parasite	Infection
MMV024101 shows potency against P. falciparum NF54 with an IC₅₀ value of 543 nM, which has antiplasmodial activity .

HY-N8385

19,20-Epoxycytochalasin C	Parasite Endogenous Metabolite	Infection Cancer
19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-P2087

Bassianolide	Insecticide Parasite Bacterial	Infection
Bassianolide is a cyclooligomer depsipeptide secondary metabolite. Bassianolide is an insecticidal virulence factor of Beauveria bassiana. Bassianolide inhibits acetylcholine-induced smooth muscle contraction, and shows moderate antiplasmodial and anti-mycobacterial activities .

HY-N3497

Isochamaejasmin	NF-κB DNA/RNA Synthesis Parasite Apoptosis	Infection Cancer
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum*) and relatively low cytotoxicity (CC₅₀ of 29.0 μM) .

HY-174130

PI4Kβ/PKG-IN-1	Parasite PI4K PKG	Infection
PI4Kβ/PKG-IN-1 (Compound 19) is an orally active dual inhibitor targeting Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG). PI4Kβ/PKG-IN-1 exhibits potent antiplasmodial activity. PI4Kβ/PKG-IN-1 is promising for research of malaria .

HY-P1638

Isariin A	Parasite	Infection
Isariin A is a cyclodepsipeptide isolated from the fungus Isaria cretacea, which exhibits antimalarial activity .

HY-N12538

trans-Cinnamic anhydride	Parasite	Infection
trans-Cinnamic anhydride is a Parasite inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .

HY-P1992

Isariin B	Parasite	Infection
Isariin B is a cyclodepsipeptide isolated from the fungus Isaria felina, which exhibits antimalarial activity .

HY-N10624

Koshidacin B	Parasite	Infection
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against *P. falciparum* FCR3 and K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection .

HY-N8476

Sahandol	Parasite	Infection
Sahandol is a diterpene, that can be isolated from Salvia sahendica. Sahandol shows antiplasmodial, antitrypanosomal, and cytotoxic activities .

HY-N3301

Melilotigenin C	Parasite Bacterial	Infection
Melilotigenin C can be isolated from genus Erythrina. Melilotigenin C can be used for research on antiplasmodial activity, antimycobacterial activity and cytotoxicity .

HY-N15403

Acetylcaranine	Parasite	Infection Cancer
Acetylcaranine is a alkaloids that can isolated from bulbs of Amaryllis belladonna Steud. Acetylcaranine shows exhibited strong antiplasmodial activity and anticancer activity .

HY-163063

Antimalarial agent 34	Parasite	Infection
Antimalarial agent 34 is a modest PfARK1/3 inhibitor and shows potent antiplasmodial activity (EC₅₀ = 0.16 μM) .

HY-156843

Antiproliferative agent-38	Nucleoside Antimetabolite/Analog	Cancer
Antiproliferative agent-38 (com 18) is a tetracyclic ring, but its most reactive ring nitrogen (probably the quinoline moiety) cannot undergo N-alkylation. Antiproliferative agent-38 lacks anti-malarial activity and lacks anti-cancer cell proliferation activity .

HY-N8383

Butyrolactone V	Parasite	Infection
Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC₅₀ of 7.9 µg/ml .

HY-132906

Antimalarial agent 3	Parasite	Infection
Antimalarial agent 3 shows nanomolar antiplasmodial activity (IC₅₀ = 0.035 μM) and has a very high selectivity index with respect to mammalian cells.

HY-N5107

Epimagnolin A (+)-epi-Magnolin	Parasite	Infection
Epimagnolin A, a furfuran lignan, shows mild antiplasmodial activities (IC₅₀=5.7 μg/mL) without noticeable toxicity on mammalian normal cells .

HY-148180

Antimycobacterial agent-4	Bacterial Parasite	Infection
Antimycobacterial agent-4 is a 2-amino-4-(2-pyridyl) thiazole derivative, with antimycobacterial activity, antiplasmodial activity, and cytotoxicity on a mammalian cell line .

HY-136943

K-41	Antibiotic Parasite Bacterial	Infection
K-41 is an orally active antibiotic. K-41 can be obtained from Streptomyces hygroscopicus. K-41 has antibacterial and antiplasmodial activity .

HY-168208

Antimalarial agent 45	Parasite	Infection
Antimalarial agent 45 (compound 8I) is a antimalarial agent and shows antiplasmodial activity the IC₅₀ of 0.21 μM. Antimalarial agent 45 can be used for study of malaria .

HY-161171

Antimalarial agent 37	Parasite Ephrin Receptor	Cancer
Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7 .

HY-N2903

Artoheterophyllin B	Parasite	Infection
Artoheterophyllin B can be isolated from A. heterophyllus. Artoheterophyllin B shows antiplasmodial activity (IC₅₀: 13.7 μM against FcB1 strain). Artoheterophyllin B can be used for anti-malarial research .

HY-W026467

MMV665916	Parasite	Infection
MMV665916, a quinazolinedione derivative, is an antimalarial agent. MMV665916 displays antiplasmodial activity against P. falciparum FcB1 strain with EC₅₀ value of 0.4 μM and presents the high selectivity index (SI>250) .

HY-169922

HDAC-IN-82	HDAC Parasite Caspase	Cancer
HDAC-IN-82 (Compound 18b) is a histone deacetylase (HDAC) inhibitor with selective antiplasmodial and anticancer activity. HDAC-IN-82 shows potent antiproliferative activity and caspase 3/7 activation in cancer cells. HDAC-IN-82 causes hyperacetylation of histone H3 and α-tubulin .

HY-N10754

Aschantin	mTOR Cytochrome P450	Infection Cardiovascular Disease Cancer
Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca ²⁺-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme .

HY-N8691

2',6'-Dihydroxy-4'-methoxydihydrochalcone	Parasite	Infection Inflammation/Immunology
2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro .

HY-172953

Insecticidal agent 24	Parasite	Infection
Insecticidal agent 24 is an orally active pyridylspiroindoline frontrunner. Insecticidal agent 24 has antiplasmodial activity (Pf NF54 IC₅₀: 0.08 μM). Insecticidal agent 24 inhibits hERG activity (IC₅₀: 6.5 μM). Insecticidal agent 24 reduces parasitemia in a humanized immunodeficient NSG mouse Plasmodium falciparum infection model .

HY-149961

Anti-inflammatory agent 40	Parasite	Infection Inflammation/Immunology
Anti-inflammatory agent 40 is a potential and orally active anti-malarial and anti-inflammatory agent. Anti-inflammatory agent 40 inhibits carrageenan induced paw swelling in vivo.

HY-N1581R

Quassin (Standard) Nigakilactone D (Standard)	Reference Standards Parasite	Infection Endocrinology
Quassin (Standard) is the analytical standard of Quassin. This product is intended for research and analytical applications. Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

Cat. No.	Nom du produit	Target	Research Area

HY-P2087

Bassianolide	Insecticide Parasite Bacterial	Infection
Bassianolide is a cyclooligomer depsipeptide secondary metabolite. Bassianolide is an insecticidal virulence factor of Beauveria bassiana. Bassianolide inhibits acetylcholine-induced smooth muscle contraction, and shows moderate antiplasmodial and anti-mycobacterial activities .

HY-P1638

Isariin A	Parasite	Infection
Isariin A is a cyclodepsipeptide isolated from the fungus Isaria cretacea, which exhibits antimalarial activity .

HY-P1992

Isariin B	Parasite	Infection
Isariin B is a cyclodepsipeptide isolated from the fungus Isaria felina, which exhibits antimalarial activity .

Cat. No.	Nom du produit	Category	Target	Chemical Structure

HY-N0740

Jatrorrhizine chloride 3 Publications Verification	Alkaloids Monophenols Coptis chinensis Franch. Ranunculaceae Phenols Plants Isoquinoline Alkaloids Source Classification	Cholinesterase (ChE) 5-HT Receptor Bacterial
Jatrorrhizine chloride is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of?AChE?(IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N0749

Jatrorrhizine	Alkaloids Monophenols other families Phenols Plants Isoquinoline Alkaloids Source Classification	Cholinesterase (ChE) 5-HT Receptor Bacterial
Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N1581

Quassin Nigakilactone D	Triterpenes Simaroubaceae Classification of Application Fields Terpenoids Plants Disease Research Fields Picrasma quassioides(D．Don)Benn． Endocrinology Source Classification	Parasite
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits *P. falciparum* with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-N0749A

Jatrorrhizine hydroxide 3 Publications Verification	Alkaloids Monophenols Coptis chinensis Franch. Ranunculaceae Phenols Plants Isoquinoline Alkaloids Source Classification	Cholinesterase (ChE) 5-HT Receptor Bacterial
Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N5109

Cheilanthifoline	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Phenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Parasite
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC₅₀s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .

HY-N6009

8-Deoxygartanin	Infection other families Xanthones Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Parasite NF-κB
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM .

HY-N8349

19,20-Epoxycytochalasin D	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Parasite Endogenous Metabolite
19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-N6251

Cratoxylone	Infection other families Xanthones Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Parasite
Cratoxylone, isolated from the bark of Cratoxylum Cochinchinense, possesses antiplasmodial activity .

HY-E70250

Neocryptolepine Cryptotackieine	Apocynaceae Cryptolepis sanguinolenta (Lindl.) Schltr. Alkaloids Plants Indole Alkaloids Source Classification	Parasite Bacterial Fungal
Neocryptolepine (Cryptotackieine) has antiplasmodial activity. Neocryptolepine also shows antibacterial activity against Gram-positive bacteria (MIC < 100 μg/mL), and antifungal activity .

HY-N5005

Guanfu base H Atisinium chloride	Infection Alkaloids Classification of Application Fields Ranunculaceae Quinoline Alkaloids Aconitum carmichaeli Debx. Plants Disease Research Fields Source Classification	Parasite
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial *Plasmodium falciparum* strains TM4/8.2 (wild type) and K1CB1 with IC₅₀ values of 4 μM and 3.6 μM, respectively .

HY-N9343

Kulactone	Triterpenes other families Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial Fungal Parasite
Kulactone, a natural bioflavonoid and an inhibitor against jRdRp, possesses antifungal, antibacterial and antiplasmodial activities. Kulactone exhibit no crossing through Blood Brain Barrier (BBB) .

HY-N4037

Homopterocarpin (-)-Homopterocarpin; 3,9-Dimethoxypterocarpan	Other Terpenoids Pterocarpus indicus willd. Structural Classification Leguminosae Terpenoids Plants Source Classification	Monoamine Oxidase Parasite
Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective, antioxidant and antiplasmodial activity. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC₅₀ and a K_i of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress .

HY-N7985

Pendulone	Infection Quinones Monophenols other families Classification of Application Fields Phenols Benzene Quinones Plants Disease Research Fields Source Classification	Parasite Bacterial
Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC₅₀ of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity .

HY-N4307

Laetanine	Infection Alkaloids Classification of Application Fields Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm. Disease Research Fields Source Classification	Parasite
Laetanine is a noraporphine alkaloid from Litsea laeta, exhibits antiplasmodial activity. Laetanine can be found in the extract of the leaves of Phoebe tavoyana (Meissn) Hook .

HY-N11031

Z-Antiepilepsirine	Alkaloids Piperidine Alkaloids Piper capense Piperaceae Plants Source Classification	Parasite
Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC₅₀ value of 27 µM for W2 strain of Plasmodium falciparum .

HY-N15748

Pelorol (-)-Pelorol	Terpenoids Sesquiterpenes Marine natural products Sponge Source Classification	Parasite
Pelorol ((-)-Pelorol) is a sesquiterpene found in the tropical marine sponge Dactylospongia elegans. Pelorol has weak antitrypanosomal activity with an IC₅₀ of 17.4 μg/mL and antiplasmodial activity against Plasmodium falciparum clones K1 and NF54 with IC₅₀ values of 786 ng/mL and 1911 ng/mL, respectively. Pelorol is promising for research of parasitic diseases, such as trypanosomiasis and malaria .

HY-N2891

Aristolactam A II Aristololactam A II	Piper longum Linn. Structural Classification Alkaloids Pyrrole Alkaloids Piperaceae Plants Source Classification	Parasite COX
Aristolactam A II (Aristololactam A II) is a weak COX inhibitor with cytotoxic and anti-plasmodial activities. Aristolactam A II exhibits inhibitory activity against Chloroquine (HY-17589A)-sensitive strains, and exerts its inhibitory effect on Plasmodium falciparum growth by inducing cell membrane damage marked by LDH release. Aristolactam A II can be applied to the research of malaria-related mechanisms .

HY-N3378

Lipiferolide	Terpenoids Sesquiterpenes Magnoliaceae Liriodendron tulipifera L. Plants Source Classification	Farnesyl Transferase Parasite
Lipiferolide is an antiplasmodial agent (IC₅₀: 1.8 μg/mL) that can be isolated from Liriodendron tulipifera. Lipiferolide also inhibits FPTase, and has antitumor activity .

HY-N1219

Stephanine (-)-Stephanine; l-Stephanine	Alkaloids Piperidine Alkaloids Plants Menispermaceae Stephania japonica (Thunb.) Miers Source Classification	Apoptosis Parasite
Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid. Stephanine induce apoptosis through the reverse of mitotic exit. Stephanine exhibits Antiplasmodial activity. Stephanine can be used for the research of stomach pain, abdominal pain, arthritis and cancer .

HY-N2932

β-Yohimbine Amsonin; Amsonine; NSC 93133	Apocynaceae Rauvolfia verticillata (Lour.) Baill. Alkaloids Aspidosperma ulei Markgr. Plants Indole Alkaloids Source Classification	Parasite
β-Yohimbine (Amsonin) is an indole alkaloid that can be isolated from Aspidosperma ulei Markgr. β-Yohimbine shows antiplasmodial activity against the Chloroquine (HY-17589A)-resistant Fc M29-Cameroon strain (IC₅₀: > 1 μg/mL) .

HY-N8385

19,20-Epoxycytochalasin C	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Parasite Endogenous Metabolite
19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-P2087

Bassianolide	Microorganisms Cyclopeptides Source Classification	Insecticide Parasite Bacterial
Bassianolide is a cyclooligomer depsipeptide secondary metabolite. Bassianolide is an insecticidal virulence factor of Beauveria bassiana. Bassianolide inhibits acetylcholine-induced smooth muscle contraction, and shows moderate antiplasmodial and anti-mycobacterial activities .

HY-N3497

Isochamaejasmin	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Other Flavonoids	NF-κB DNA/RNA Synthesis Parasite Apoptosis
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum*) and relatively low cytotoxicity (CC₅₀ of 29.0 μM) .

HY-P1638

Isariin A	Microorganisms Cyclopeptides Source Classification	Parasite
Isariin A is a cyclodepsipeptide isolated from the fungus Isaria cretacea, which exhibits antimalarial activity .

HY-N12538

trans-Cinnamic anhydride	Productos naturales Cinnamomum verum J. Presl Plants Lauraceae Source Classification	Parasite
trans-Cinnamic anhydride is a Parasite inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .

HY-P1992

Isariin B	Microorganisms Cyclopeptides Source Classification	Parasite
Isariin B is a cyclodepsipeptide isolated from the fungus Isaria felina, which exhibits antimalarial activity .

HY-N10624

Koshidacin B	Productos naturales Microorganisms	Parasite
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against *P. falciparum* FCR3 and K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection .

HY-N8476

Sahandol	Chrysanthemum × morifolium (Ramat.) Hemsl. Terpenoids Labiatae Diterpenoids Plants Source Classification	Parasite
Sahandol is a diterpene, that can be isolated from Salvia sahendica. Sahandol shows antiplasmodial, antitrypanosomal, and cytotoxic activities .

HY-N3301

Melilotigenin C	Triterpenes Structural Classification Leguminosae Terpenoids Erythrina stricta Roxb. Plants Pentacyclic Triterpenoids Source Classification	Parasite Bacterial
Melilotigenin C can be isolated from genus Erythrina. Melilotigenin C can be used for research on antiplasmodial activity, antimycobacterial activity and cytotoxicity .

HY-N15403

Acetylcaranine	Alkaloids Amaryllis belladonna L. Quinoline Alkaloids Plants Amaryllidaceae Source Classification	Parasite
Acetylcaranine is a alkaloids that can isolated from bulbs of Amaryllis belladonna Steud. Acetylcaranine shows exhibited strong antiplasmodial activity and anticancer activity .

HY-N8383

Butyrolactone V	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Source Classification	Parasite
Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC₅₀ of 7.9 µg/ml .

HY-N5107

Epimagnolin A (+)-epi-Magnolin	Infection other families Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	Parasite
Epimagnolin A, a furfuran lignan, shows mild antiplasmodial activities (IC₅₀=5.7 μg/mL) without noticeable toxicity on mammalian normal cells .

HY-136943

K-41	Microorganisms Ketones, Aldehydes, Acids Source Classification	Antibiotic Parasite Bacterial
K-41 is an orally active antibiotic. K-41 can be obtained from Streptomyces hygroscopicus. K-41 has antibacterial and antiplasmodial activity .

HY-N2903

Artoheterophyllin B	Phenols Polyphenols Plants Moraceae Source Classification	Parasite
Artoheterophyllin B can be isolated from A. heterophyllus. Artoheterophyllin B shows antiplasmodial activity (IC₅₀: 13.7 μM against FcB1 strain). Artoheterophyllin B can be used for anti-malarial research .

HY-N10754

Aschantin	Structural Classification Magnoliaceae Lignans Yulania biondii (Pamp.) D. L. Fu Phenylpropanoids Plants Source Classification	mTOR Cytochrome P450
Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca ²⁺-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme .

HY-N8691

2',6'-Dihydroxy-4'-methoxydihydrochalcone	Piper aduncum L. Phenols Polyphenols Piperaceae Plants Source Classification	Parasite
2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro .

HY-N1581R

Quassin (Standard) Nigakilactone D (Standard)	Triterpenes Structural Classification Simaroubaceae Terpenoids Plants Picrasma quassioides(D．Don)Benn． Source Classification	Reference Standards Parasite
Quassin (Standard) is the analytical standard of Quassin. This product is intended for research and analytical applications. Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-N9746

(R)-4-Methoxydalbergione	Quinones Structural Classification Ranunculus repens L. Ranunculaceae Benzene Quinones Plants Source Classification	Parasite
(R)-4-Methoxydalbergione is a urease inhibitor with IC₅₀s of 59.72 and 67.33 μM for Bacillus pasteurii urease and Jack bean urease. (R)-4-Methoxydalbergione also has antiplasmodial activity. (R)-4-Methoxydalbergione can be isolated from Ranunculus repens .

HY-N0740R

Jatrorrhizine chloride (Standard)	Alkaloids Monophenols Coptis chinensis Franch. Ranunculaceae Phenols Plants Isoquinoline Alkaloids Source Classification	Reference Standards Cholinesterase (ChE) 5-HT Receptor Bacterial
Jatrorrhizine (chloride) (Standard) is the analytical standard of Jatrorrhizine (chloride). This product is intended for research and analytical applications. Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N9475

Betulonaldehyde	Triterpenes Betula alleghaniensis Britton Terpenoids Plants Betulaceae Source Classification	Parasite
Betulonaldehyde is a pentacyclic triterpenoid that can be isolated from Diospyros filipendula. Betulonaldehyde has antiplasmodial activity (IC₅₀: 3.36 µg/mL). Betulonaldehyde has cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC₅₀s: 19.23 and 17.09 µg/mL, respectively). Betulonaldehyde inhibits Phorbol 12-myristate 13-acetate (HY-18739) induced inflammation in mice .

HY-N18356

Europetin 7-O-Methylmyricetin	Structural Classification Flavonoids Flavones Citrus × aurantiifolia (Christmann) Swingle Rutaceae Phenols Plants Source Classification	Others
Europetin (7-O-Methylmyricetin) is a natural product. Europetin can be isolated from the peels of Citrus aurantifolia. Europetin shows no antiplasmodial activity against Plasmodium falciparum NF54 with an IC₅₀ > 50 μM. Europetin can be used for the research of malaria .

HY-W800535

Cryptolepine	Malvaceae Structural Classification Alkaloids Sida acuta Burm. F. Quinoline Alkaloids Plants Indole Alkaloids Source Classification	NF-κB p38 MAPK mTOR Topoisomerase AMPK Apoptosis Cholinesterase (ChE) HIF/HIF Prolyl-Hydroxylase β-catenin
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of c-Myc, mTOR, NF-κB, HIF-1, MAPK and an activator of AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection .

HY-N18091

Tovophyllin A	Structural Classification Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants Source Classification	Akt GSK-3 Keap1-Nrf2 NF-κB Apoptosis
Tovophyllin A is an orally active xanthonoid compound. Tovophyllin A exerts neuroprotective effects against Parkinson's disease by activating the Akt/GSK3β signaling pathway. Tovophyllin A protects mouse models of liver injury by activating Nrf2. Tovophyllin A exhibits protective anti-inflammatory activity in mouse models of acute lung injury. Tovophyllin A inhibits the activation of NF-κB and subsequent release of pro-inflammatory cytokines. Tovophyllin A reduces apoptotic cell death (Apoptosis). Tovophyllin A has antiplasmodial activity. Tovophyllin A shows cytotoxic activity against lung epithelial cancer cells and breast cancer cells. Tovophyllin A can be used in research related to Parkinson's disease, liver injury, acute lung injury, lung epithelial cancer, and breast cancer .

HY-W099725

Sarmentine	Piper longum Linn. Structural Classification Alkaloids Pyrrole Alkaloids Piperaceae Plants Source Classification	Herbicide Photosystem II
Sarmentine is a broad-spectrum contact herbicide and PSII inhibitor, with an IC₅₀ of 3.0 μM and a K_i of 1.5 μM against spinach, an IC₅₀ of 1.72 μM against wild-type Amaranthus retroflexus, and an IC₅₀ of 0.97 μM against triazine-resistant Amaranthus retroflexus. Sarmentine competitively binds to the Q_B binding site of plastoquinone on PSII, thereby blocking photosynthetic electron transport. Sarmentine inhibits enoyl-ACP reductase in Arabidopsis thaliana by targeting the early fatty acid synthesis process, with an IC₅₀ of 18.3 μM. Sarmentine induces light-independent loss of plasma membrane integrity and electrolyte leakage. Sarmentine also exhibits antiplasmodial, antimycobacterial, antituberculous, and antiplatelet aggregation activities .

Cat. No.	Nom du produit	Chemical Structure

HY-W778649

Sarmentine-d8

Sarmentine-d₈ is the deuterium labeled Sarmentine. Sarmentine is a broad-spectrum contact herbicide and PSII inhibitor, with an IC₅₀ of 3.0 μM and a K_i of 1.5 μM against spinach, an IC₅₀ of 1.72 μM against wild-type Amaranthus retroflexus, and an IC₅₀ of 0.97 μM against triazine-resistant Amaranthus retroflexus. Sarmentine competitively binds to the Q_B binding site of plastoquinone on PSII, thereby blocking photosynthetic electron transport. Sarmentine inhibits enoyl-ACP reductase in Arabidopsis thaliana by targeting the early fatty acid synthesis process, with an IC₅₀ of 18.3 μM. Sarmentine induces light-independent loss of plasma membrane integrity and electrolyte leakage. Sarmentine also exhibits antiplasmodial, antimycobacterial, antituberculous, and antiplatelet aggregation activities .

Cat. No.	Nom du produit		Classification

HY-133192

Bis-propargyl-PEG3		Alkynes PROTAC Synthesis
Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity . Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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