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Cat. No.: HY-183238

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Antimalarial agent 61

Antimalarial agent 61 is an antimalarial agent. Antimalarial agent 61 disrupts hemoglobin breakdown in Plasmodium falciparum asexual blood stage trophozoites. Antimalarial agent 61 exerts antiplasmodial activity against Chloroquine (HY-17589A)-sensitive Plasmodium falciparum parasites. Antimalarial agent 61 can be used for the research of malaria.

For research use only. We do not sell to patients.

Formula: C₃₄H₃₆N₄O₄
Molecular Weight:564.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimalarial agent 61 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Plasmodium falciparum sporozoites

All Parasite Isoforms :

In Vitro

Antimalarial agent 61 (Compound 33) (20 μM) potently inhibits Plasmodium falciparum 3D7 parasite growth with an IC₅₀ of 0.08 μM and shows minimal cytotoxicity to HeLa cells (IC₅₀ >20 μM)^[1].
Antimalarial agent 61 (0.8 μM; 2.5 h) disrupts hemoglobin catabolism in Plasmodium falciparum 3D7 trophozoites and exhibits a distinct metabolic profile suggesting additional mechanistic pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 564.67
Formula C₃₄H₃₆N₄O₄
SMILES

O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(OC)C=C3OC)N14)NC5=C2C=CC=C5)N(C6CCN(CC7=CC=CC=C7)CC6)CC4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Elhalawaty EA, et al. Effect of Stereochemistry on the Antiplasmodial Activity and Metabolomic Profile of Novel Tadalafil Analogues. ACS Med. Chem. Lett. 2026 Apr 14.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Antimalarial agent 61

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Antimalarial agent 61 Related Classifications

HY-183238 Related Classifications