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  3. Parasite
  4. Antimalarial agent 61

Antimalarial agent 61 is an antimalarial agent. Antimalarial agent 61 disrupts hemoglobin breakdown in Plasmodium falciparum asexual blood stage trophozoites. Antimalarial agent 61 exerts antiplasmodial activity against Chloroquine (HY-17589A)-sensitive Plasmodium falciparum parasites. Antimalarial agent 61 can be used for the research of malaria.

For research use only. We do not sell to patients.

Antimalarial agent 61

Antimalarial agent 61 Chemical Structure

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Antimalarial agent 61 Related Antibodies

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Description

Antimalarial agent 61 is an antimalarial agent. Antimalarial agent 61 disrupts hemoglobin breakdown in Plasmodium falciparum asexual blood stage trophozoites. Antimalarial agent 61 exerts antiplasmodial activity against Chloroquine (HY-17589A)-sensitive Plasmodium falciparum parasites. Antimalarial agent 61 can be used for the research of malaria[1].

IC50 & Target[1]

Plasmodium falciparum sporozoites

 

In Vitro

Antimalarial agent 61 (Compound 33) (20 μM) potently inhibits Plasmodium falciparum 3D7 parasite growth with an IC50 of 0.08 μM and shows minimal cytotoxicity to HeLa cells (IC50 >20 μM)[1].
Antimalarial agent 61 (0.8 μM; 2.5 h) disrupts hemoglobin catabolism in Plasmodium falciparum 3D7 trophozoites and exhibits a distinct metabolic profile suggesting additional mechanistic pathways[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 61 Related Antibodies
Molecular Weight

564.67

Formula

C34H36N4O4
SMILES

O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(OC)C=C3OC)N14)NC5=C2C=CC=C5)N(C6CCN(CC7=CC=CC=C7)CC6)CC4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antimalarial agent 61 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 61Antimalarial agent61Antimalarial agent-61ParasitePlasmodium falciparumβ-hematinmalariachloroquine-sensitive Plasmodium falciparum parasitescervical cancer cellsasexual blood stage trophozoiteshemoglobin breakdownHeLa cellsPlasmodium falciparum 3D7hemoglobin catabolismInhibitorinhibitorinhibit

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