Isochamaejasmin
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells. Isochamaejasmin also has a moderate antiplasmodial activity (IC50 of 7.3 μM for P. falciparum) and relatively low cytotoxicity (CC50 of 29.0 μM).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 93859-63-3
- Formule: C30H22O10
- Masse moléculaire:542.49
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis
MoreVoir tous les produits spécifiques à Isoform Parasite
More
Activité biologique
Isochamaejasmin (6.25-100 μM; 24-72 h) shows potential toxicity against AW1 cells via time- and dose-dependent manners. Isochamaejasmin (1000 mg/L, 500 mg/L, 250 mg/L, 125 mg/L, 62.5 mg/L; 24 h, 48 h, 72 h, and 96 h) has potential toxicity against H. zea larvae via time- and dose-dependent manners[1].
Isochamaejasmin (40-80 μM; 24 h) causes DNA damage and increases the levels of γH2AX and OGG1 in AW1 cells. The cell cycle is arrested at the G2/M phase[1].
Isochamaejasmin (20-80 μM; 24 h) induces apoptosis of AW1 cells in a dose-dependent manner[1].
Isochamaejasmin (20-80 μM; 24 h) shows decline in the MMP, upregulation of Bax/Bcl-2 expression resulting in the release of cytochrome c into the cytosol, activation of caspase-3/9, and cleavage of PARP[1].
Isochamaejasmin shows a dose-dependent rise in the reactive oxygen species (ROS) levels, accumulation of a lipid peroxidation product, and inactivation of antioxidant enzymes in AW1 cells[1].
Isochamaejasmin induces the expression of a NF-κB-directed reporter gene in transfected HeLa cells with an EC50 of 3.23 μM. The Isochamaejasmin-stimulated NF-κB reporter activity is accompanied by nuclear translocation of NF-κB proteins and is blocked by a dominant-negative construct of IκBα. Isochamaejasmin also induces time-dependent phosphorylation of the mitogen-activated protein kinases ERK1/2 and p38, and PKCδ[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Larvae and neuronal cells (AW1)
-
Concentration:6.25 μM, 12.5 μM, 25 μM, 50 μM and 100 μM
-
Incubation Time:24 h, 48 h and 72 h
-
Result:Had potential toxicity against H. zea both in vivo and in vitro via time- and dose-dependent manners.
-
Cell Line:Neuronal cells (AW1)
-
Concentration:40 μM and 80 μM
-
Incubation Time:24 h
-
Result:The cell cycle was arrested at the G2/M phase.
-
Cell Line:Neuronal cells (AW1)
-
Concentration:20 μM, 40 μM, and 80 μM
-
Incubation Time:24 h
-
Result:Induced apoptosis via the mitochondrial pathway in AW1 cells.
-
Cell Line:Neuronal cells (AW1)
-
Concentration:20 μM, 40 μM, and 80 μM
-
Incubation Time:24 h
-
Result:Showed upregulation of Bax/Bcl-2 expression resulting in the release of cytochrome c into the cytosol, activation of caspase-3/9, and cleavage of PARP.
Chemical Information
-
CAS No. 93859-63-3
-
Masse moléculaire 542.49
-
Formule C30H22O10
-
SMILES
O=C1[C@]([C@]2([H])[C@@H](C3=CC=C(O)C=C3)OC4=CC(O)=CC(O)=C4C2=O)([H])[C@H](C5=CC=C(O)C=C5)OC6=CC(O)=CC(O)=C16
-
Structure Classification
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Yuanhang Ren, et al. Isochamaejasmin induces toxic effects on Helicoverpa zea via DNA damage and mitochondria-associated apoptosis. Pest Manag Sci. 2021 Jan;77(1):557-567. [Content Brief]
[2]. Qinghai Tian, et al. Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Mol Pharmacol. 2005 Dec;68(6):1534-42. [Content Brief]
[3]. Liene Dhooghe, et al. Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii. Phytochemistry. 2010 May;71(7):785-91. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isochamaejasmin Related Classifications
HY-N3497 Related Classifications
Powered by Bioz