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  3. Parasite
  4. Cycotiamine

Cycotiamine is an S-acylated thiamine derivative with antiplasmodial activity. Cycotiamine inhibits the proliferation of Plasmodium falciparum and Plasmodium knowlesi. Cycotiamine can be used in malaria-related research.

For research use only. We do not sell to patients.

Cycotiamine

Cycotiamine Chemical Structure

CAS No. : 6092-18-8

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Cycotiamine Related Antibodies

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Description

Cycotiamine is an S-acylated thiamine derivative with antiplasmodial activity. Cycotiamine inhibits the proliferation of Plasmodium falciparum and Plasmodium knowlesi. Cycotiamine can be used in malaria-related research[1].

In Vitro

Cycotiamine (compound 12) exhibits IC50 values of 123 μM, 127 μM, and 176 μM against P. falciparum under extracellular thiamine concentrations of 0 μM, 2.97 μM, and 297 μM, respectively. The IC50 of cycotiamine against P. knowlesi exceeds 1000 μM, showing weaker anti-parasitic activity than other thiamine analogs in the same series. The IC50 of cycotiamine against human fibroblast HFF cells exceeds 1000 μM, with no obvious cytotoxicity[1].
Cycotiamine (serial dilution; 96 h) inhibits the proliferation of both Plasmodium falciparum strain 3D7-GFP and PfTPK-GFP-overexpressing Plasmodium to the same extent, indicating that its anti-Plasmodium effect is independent of thiamine pyrophosphokinase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cycotiamine Related Antibodies
Molecular Weight

308.36

Formula

C13H16N4O3S
CAS No.
SMILES

O=CN(CC1=CN=C(C)N=C1N)/C(C)=C2SC(OCC/2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cycotiamine Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cycotiamine6092-18-8Parasitehuman foreskin fibroblastsPlasmodium falciparum strain 3D7Plasmodium falciparumpyrimidine ringfatty acidsPlasmodium knowlesiPlasmodium knowlesi strain H1malariahuman fibroblaststhiamine pyrophosphokinaseInhibitorinhibitorinhibit

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