Antimalarial agent 33
Based on 1 Customer Validation
Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC50 of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes.
For research use only. We do not sell to patients.
- Purity: 99.13%
- CAS No.: 3053680-00-2
- Formula: C17H17N3OS
- Molecular Weight:311.40
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | CC50 |
>100 μM
Compound: 5g
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Cytotoxicity against Cynomolgous monkey hepatocytes harboring Simian virus assessed as reduction in cell viability administered for 3 hrs followed by replacement with fresh medium containing compound for every 24 hrs by DAPI staining based analysis
Cytotoxicity against Cynomolgous monkey hepatocytes harboring Simian virus assessed as reduction in cell viability administered for 3 hrs followed by replacement with fresh medium containing compound for every 24 hrs by DAPI staining based analysis
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[PMID: 37857143] |
| HepG2 | CC50 |
14 μM
Compound: 5g
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 37857143] |
Chemical Information
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CAS No. 3053680-00-2
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Appearance Solid
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Molecular Weight 311.40
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Formula C17H17N3OS
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Color White to off-white
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SMILES
CC1=CC=C(C2=CC(N=C(NC3CCC3)NC4=O)=C4S2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 5 mg/mL (16.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2113 mL | 16.0565 mL | 32.1130 mL | 80.2826 mL |
| 5 mM | 0.6423 mL | 3.2113 mL | 6.4226 mL | 16.0565 mL | |
| 10 mM | 0.3211 mL | 1.6057 mL | 3.2113 mL | 8.0283 mL | |
| 15 mM | 0.2141 mL | 1.0704 mL | 2.1409 mL | 5.3522 mL |
Antimalarial agent 33 Related Classifications
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