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  3. Quassin

Quassin (Synonyms: Nigakilactone D)

Cat. No.: HY-N1581
Handling Instructions

Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity.

For research use only. We do not sell to patients.

Quassin Chemical Structure

Quassin Chemical Structure

CAS No. : 76-78-8

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Description

Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity[1][2].

IC50 & Target

IC50: 0.15 μM (P. falciparum)[2]

In Vitro

Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion[3].

In Vivo

Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats[1].

Animal Model: 35 females albino rats (150-170 g)[1]
Dosage: 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg
Administration: Oral administration; daily; for 60 days
Result: There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats.
Molecular Weight

388.45

Formula

C₂₂H₂₈O₆

CAS No.

76-78-8

SMILES

C[[email protected]@H]([[email protected]@]1(C[[email protected]]2(OC(C[[email protected]]([[email protected]]2([[email protected]]3([[email protected]@]41C)[H])C)(C(C)=C(OC)C3=O)[H])=O)[H])[H])C=C(OC)C4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

QuassinNigakilactone DParasiteReproductiveorallyestrogensecretionantifertilityanti-estrogenictestosteroneanti-plasmodialInhibitorinhibitorinhibit

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Quassin
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