Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro

  • Planta Med. 1995 Apr;61(2):180-2. doi: 10.1055/s-2006-958044.
V C Njar ,  T O Alao ,  J I Okogun ,  Y Raji ,  A F Bolarinwa ,  E U Nduka
PMID: 7753928 DOI: 10.1055/s-2006-958044
Abstract

The crude methanol Extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the Extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.

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