K-41 

K-41 is an orally active antibiotic. K-41 can be obtained from Streptomyces hygroscopicus. K-41 has antibacterial and antiplasmodial activity^[1][2].

K-41 inhibits K1 and FCR3 strains of Plasmodium falciparum, with IC₅₀s of 8.5 and 31 nM^[1].
K-41 inhibits B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumonia, C. diphtheria, and M. tuberculosis, with MICs of 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/mL, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

K-41 (p.o.) inhibits P. berghei and P. yoelii infection in mice, with ED₅₀s of 1.9 and 7.0 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

947.15

C₄₈H₈₂O₁₈

53026-37-2

C[C@H]([C@H]1OC)[C@](O[C@@H](C2)C[C@H](O[C@]3(O)[C@@H](O)C(O)=O)[C@@](C)([C@H]([C@@H]3C)OC)OC)([C@@H]([C@@H]2OC)C)O[C@@]1([C@]4([H])O[C@@]([C@]5([H])O[C@]([C@](O[C@@]6(O)C)([H])[C@H]([C@@H]([C@H]6C)O[C@@H](CC[C@@H]7OC)O[C@@H]7C)C)([H])CC5)([H])CC4)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Otoguro K, et al. In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia. J Antibiot (Tokyo). 2002 Sep;55(9):832-4.  [Content Brief]

  [2]. Tsuji N, et al. Two new antibiotics, A-218 and K-41. Isolation and characterization. J Antibiot (Tokyo). 1976 Jan;29(1):10-4.  [Content Brief]