LSPN959 

LSPN959 is a slow-acting indole peptidomimetic antiplasmodial agent with submicromolar activity against the Plasmodium falciparum 3D7 strain. LSPN959 does not inhibit plastid-dependent isoprenoid biosynthesis. The combination of LSPN959 with Artesunate (HY-N0193) exhibits an additive effect against Plasmodium falciparum. LSPN959 can be used in malaria research^[1].

LSPN959 (0.049-50 μM; 72 h) potently inhibits chloroquine-sensitive Plasmodium falciparum 3D7 strain growth with an IC₅₀ of 1.05 μM, exhibits low cytotoxicity against human HepG2 and HEK293 cells, and has a high selectivity index of 95^[1].
LSPN959 (0.049-50 μM; 24-72 h) exhibits a slow-acting inhibitory profile against Plasmodium falciparum 3D7 strain, with IC₅₀ ratios and morphological observations consistent with delayed parasite killing and recovery potential post-exposure^[1].
LSPN959 (72 h)'s antiplasmodial activity against Plasmodium falciparum 3D7 strain is not reversed by IPP supplementation, indicating it does not inhibit apicoplast-dependent isoprenoid biosynthesis^[1].
LSPN959 (72 h) exhibits an additive interaction when combined with Artesunate against Plasmodium falciparum 3D7 strain, with no statistically significant synergy or antagonism observed^[1].
LSPN959 (0.049-50 μM; 72 h) retains potent antiplasmodial activity against multidrug-resistant Plasmodium falciparum strains (3D7^R_MMV848, Dd2R_DSM265, Dd2, K1, TM90C6B) with resistance indices close to 1, showing no cross-resistance with standard antimalarials^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

629.59

C₃₄H₃₇BrN₄O₃

CC(C)(NC(CN(C(C1=CC=CC=C1)=O)CC(C2=CC3=CC=CC=C3N2C(N4CCCC4)=O)C5=CC=C(C=C5)Br)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Januário MA, et al. Indole Peptidomimetics Show Potent and Selective Activity against Drug-Resistant Plasmodium falciparum. ACS Omega. 2026 Mar 21.