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Cat. No.: HY-132906

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Antimalarial agent 3

Antimalarial agent 3 shows nanomolar antiplasmodial activity (IC₅₀ = 0.035 μM) and has a very high selectivity index with respect to mammalian cells.

For research use only. We do not sell to patients.

CAS No.: 3033386-12-5
Formula: C₁₅H₁₆BrN₃O₂
Molecular Weight:350.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Antimalarial agent 3 Chemical Structure

CAS No.: 3033386-12-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Antimalarial agent 3 shows nanomolar antiplasmodial activity (IC₅₀ = 0.035 μM) and has a very high selectivity index with respect to mammalian cells.

IC₅₀ & Target

Plasmodium

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	IC₅₀	40 μM Compound: 12	Cytotoxicity against mouse BMDM cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against mouse BMDM cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 34795860]

Chemical Information

CAS No. 3033386-12-5
Molecular Weight 350.21
Formula C₁₅H₁₆BrN₃O₂
SMILES

CC(C1=CC=C(C2=NN=C(C3CC(Br)=NO3)O2)C=C1)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Galbiati A, et al. Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds. ACS Med Chem Lett. 2021 Oct 13;12(11):1726-1732. [Content Brief]

Calculators

Molarity Calculator

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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