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Results for "

Casein+Kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (3) Akt (2) Apoptosis (14) ATP Synthase (1) Autophagy (8) Biochemical Assay Reagents (1) CaMK (1) Casein Kinase (107) Caspase (1) CDK (7) Creatine Kinase (1) DYRK (2) Epigenetic Reader Domain (2) ERK (1) FLT3 (1) HDAC (1) HSP (1) Isotope-Labeled Compounds (1) Ligands for E3 Ligase (1) MDM-2/p53 (2) Mitochondrial Metabolism (1) Molecular Glues (4) p38 MAPK (11) PASK/STK37 (1) Phosphodiesterase (PDE) (2) PI3K (8) Pim (1) PKA (3) PKC (3) Reactive Oxygen Species (ROS) (1) Reference Standards (7) Ribosomal S6 Kinase (RSK) (2) SARS-CoV (3) Ser/Thr Protease (1) SGK (2) Survivin (1) Wee1 (1) Wnt (6)
By Research Areas:	Cancer (58) Cardiovascular Disease (3) Inflammation/Immunology (11) Metabolic Disease (5) Neurological Disease (39)
Oligonucleotides:	Nucleoside Analogs (1)

115

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15979

H-89 Maximum Cited Publications 179 Publications Verification	PKA Autophagy	Neurological Disease
H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (*protein kinase* A) with IC₅₀** of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase, and others kinases.

HY-15979A

H-89 dihydrochloride Maximum Cited Publications 179 Publications Verification	PKA Autophagy	Others
H-89 dihydrochloride is a potent and selective inhibitor of protein kinase A (PKA) with an IC₅₀ of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase.

HY-14392

5,6-Dichlorobenzimidazole riboside 5+ Cited Publications DRB	CDK Apoptosis	Cancer
5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including *casein kinase* II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis .

HY-15490

PF-670462 dihydrochloride 5+ Cited Publications	Casein Kinase	Cancer
PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase (CK1ε and CK1δ), with IC₅₀s of 7.7 nM and 14 nM, respectively.

HY-10324

D4476 10+ Cited Publications Casein Kinase I Inhibitor	Casein Kinase Autophagy Apoptosis	Cancer
D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1) with an IC₅₀ value of 0.3 μM in vitro.

HY-12279

Umbralisib 5 Publications Verification TGR-1202; RP5264	PI3K Casein Kinase	Cancer
Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC₅₀ of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach .

HY-123954

BTX-A51 1 Publications Verification Casein Kinase inhibitor A51	Casein Kinase CDK Apoptosis	Cancer
BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities .

HY-14394

TBB 10+ Cited Publications NSC 231634; Casein Kinase II Inhibitor I	Casein Kinase	Cancer
TBB is a cell-permeable and ATP-competitive CK2 inhibitor with an IC₅₀ of 0.15 μM for rat liver CK2.

HY-10456

TAK-715 10+ Cited Publications	p38 MAPK Casein Kinase Wnt	Inflammation/Immunology
TAK-715 is an orally active and potent p38 MAPK inhibitor with IC₅₀s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model .

HY-159646

BMS-986397	Molecular Glues Ligands for E3 Ligase Casein Kinase Apoptosis MDM-2/p53	Inflammation/Immunology Cancer
BMS-986397 is a potent, selective, and orally active cereblon-based molecular glue degrader of casein kinase 1α (CK1α). BMS-986397 induces apoptosis and cell cycle arrest in acute myeloid leukemia (AML) cells. BMS-986397 is a promising agent for the investigation of AML and high-risk myelodysplastic syndromes (HR-MDS) .

HY-15535

DMAT 5+ Cited Publications CK2 Inhibitor; Casein kinase II Inhibitor	Casein Kinase	Cancer
DMAT is a potent and specific CK2 inhibitor with an IC₅₀ value of 130 nM.

HY-12470

PF-4800567 2 Publications Verification	Casein Kinase	Others
PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC₅₀ of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC₅₀, 711 nM).

HY-W011109

CKI-7 1 Publications Verification	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, *ribosomal S6 kinase-1 (S6K1)* and *mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase* II and other protein kinases .

HY-P1821

Myelin Basic Protein 2 Publications Verification MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-129571

BioE-1115	PASK/STK37 Ser/Thr Protease Casein Kinase	Metabolic Disease
BioE-1115 is a highly selective and potent *PAS kinase* (PASK) inhibitor with an IC₅₀** of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC₅₀ of ~10 μM .

HY-145322

TMX-4116	Casein Kinase Molecular Glues	Cancer
TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC₅₀s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma .

HY-111820

CK1-IN-1	Casein Kinase p38 MAPK	Cardiovascular Disease
CK1-IN-1 (Compound 1c) is a casein kinase 1 (CK1) inhibitor with IC₅₀ values of 15 nM and 16 nM for CK1δ and CK1ε, respectively. CK1-IN-1 inhibits p38α MAPK with an IC₅₀ of 73 nM. CK1-IN-1 can be used to study cardiomyogenesis .

HY-108642

AMG-548	p38 MAPK Casein Kinase	Inflammation/Immunology
AMG-548, an orally active and selective p38α inhibitor (K_i=0.5 nM), shows slightly selective over p38β (K_i=36 nM) and >1000 fold selective against p38γ and p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC₅₀=3 nM) . AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε .

HY-120675

SSTC3 2 Publications Verification	Casein Kinase Wnt	Cancer
SSTC3 is a casein kinase 1α (CK1α) activator (K_d = 32 nM) that inhibits WNT signaling (EC₅₀ = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors .

HY-133028

CKI-7 free base 1 Publications Verification	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, *ribosomal S6 kinase-1 (S6K1)* and *mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase* II and other protein kinases .

HY-119751

Hematein 1 Publications Verification	Casein Kinase Akt Wnt Apoptosis	Cancer
Hematein is a oxidation product of hematoxylin acted as a dye . Hematein is an allosteric casein kinase II inhibitor with an IC₅₀ of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells .

HY-108606

PI-828 2 Publications Verification	PI3K Casein Kinase	Cancer
PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC₅₀s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively .

HY-145319

FPFT-2216	Phosphodiesterase (PDE) Casein Kinase Molecular Glues	Inflammation/Immunology Cancer
FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease .

HY-148455

Casein kinase 1δ-IN-3	Casein Kinase	Neurological Disease
Casein kinase 1δ-IN-3 (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC₅₀ of 6.5376 M .

HY-115519

(E/Z)-GO289 2 Publications Verification	Casein Kinase	Cancer
(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC₅₀=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function .

HY-P3815

Casein Kinase 2 Substrate Peptide 2 Publications Verification	Casein Kinase	Others
Casein Kinase 2 Substrate Peptide is a common CK2 substrate peptide. Casein Kinase 2 Substrate Peptide is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). Casein Kinase 2 Substrate Peptide can be used for protein kinase CK2 activity determination .

HY-168654

WEE1 degrader 1	Wee1	Cancer
WEE1 degrader 1 (Compound 10) is a CRBN-dependent molecular glue degrader of WEE1 and casein kinase 1α (CK1α) with sub-2 nM DC₅₀ values for both targets. WEE1 degrader 1 can be used for the research of acute lymphoblastic leukemia, acute monocytic leukemia, acute promyelocytic leukemia, colorectal adenocarcinoma, diffuse large b cell lymphoma .

HY-108642B

AMG-548 dihydrochloride	p38 MAPK Casein Kinase	Inflammation/Immunology
AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (K_i=0.5 nM), shows slightly selective over p38β (K_i=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC₅₀=3 nM) . AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε .

HY-123955

Casein Kinase inhibitor A86	Casein Kinase CDK Apoptosis	Cancer
Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities .

HY-110052

TBCA 1 Publications Verification	Casein Kinase	Cancer
TBCA is a highly selective *CK2 (casein kinase* II) inhibitor with an IC₅₀ of 110 nM and a K_i** of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases .

HY-114858

Epiblastin A 1 Publications Verification	Casein Kinase	Cancer
Epiblastin A is an ATP competitive casein kinase 1 (CK1) inhibitor with IC₅₀s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1 .

HY-12279C

Umbralisib hydrochloride 5 Publications Verification TGR-1202 hydrochloride; RP5264 hydrochloride	PI3K Casein Kinase	Cancer
Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC₅₀ of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach .

HY-148233S

JNJ-6204	Casein Kinase	Others
JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC₅₀=2.3 nM; CSNK1E IC₅₀=137 nM). JNJ-6204 shows good brain exposure .

HY-145320

TMX-4113	Molecular Glues Phosphodiesterase (PDE) Casein Kinase	Cancer
TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer .

HY-148112

Casein kinase 1δ-IN-1	Casein Kinase	Neurological Disease
Casein kinase 1δ-IN-1 is an inhibitor of casein kinase 1δ (CK1δ). Casein kinase 1δ-IN-1 can be used for the research of neurodegenerative diseases such as tauopathies .

HY-P4056A

CIGB-300 acetate P15-Tat acetate	Casein Kinase Apoptosis	Cancer
CIGB-300 acetate (P15-Tat acetate) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase CK2. CIGB-300 acetate induces apoptosis in multiple tumor cell lines and can be used in cancer research .

HY-E70625

Casein Kinase 2	Casein Kinase	Cancer
Casein Kinase 2 (CK2) is a serine/threonine protein kinase that is highly conserved among eukaryotes and has roles in many different cellular processes, such as cell survival, cell cycle regulation, cell polarity, stress responses, transcription and translation .

HY-P3921

Casein Kinase II Substrate	Casein Kinase	Cancer
Casein Kinase II Substrate is a casein kinase II (CK2) peptide substrate that can be selectively phosphorylated by CK2 .

HY-111378

Casein Kinase II Inhibitor IV	Casein Kinase	Metabolic Disease
Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC₅₀ of 9 nM. Casein Kinase II Inhibitor IV ia also a human keratinocytes (NHEK) differentiation inducer .

HY-128677

NCC007	Casein Kinase	Neurological Disease
NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC₅₀s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms .

HY-P4056

CIGB-300 P15-Tat	Casein Kinase Apoptosis	Cancer
CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase CK2. CIGB-300 induces apoptosis in multiple tumor cell lines and can be used in cancer research .

HY-P1821A

Myelin basic protein (4-14) TFA 2 Publications Verification MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-125957

A-3 hydrochloride	PKA Casein Kinase CaMK PKC	Others
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various *kinases. It against PKA (K_i=4.3 µM), casein kinase* II (K_i=5.1 µM) and myosin light chain kinase (MLCK) (K_i=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 µM and 80 µM, respectively .

HY-P1909

Casein Kinase Substrates 3	Casein Kinase	Cancer
Casein Kinase Substrates 3 is a substrate of casein kinase.

HY-103384

TMCB	Casein Kinase	Cancer
TMCB is a selective, ATP-competitive *CK2 (casein kinase* II) inhibitor with distinct K_i** values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively .

HY-153904

Casein kinase 1δ-IN-5	Casein Kinase	Neurological Disease
Casein kinase 1δ-IN-5 is a potent and selective protein kinase CK-1δ inhibitor with an IC₅₀ of 47 nM. Casein kinase 1δ-IN-5 shows neuroprotective and anti-inflammatory properties both in vitro. Casein kinase 1δ-IN-5 has the potential for neurodegenerative diseases research.

HY-153905

Casein kinase 1δ-IN-6	Casein Kinase	Neurological Disease
Casein kinase 1δ-IN-6 is a potent and selective protein kinase CK-1δ inhibitor with an IC₅₀ of 23 nM. Casein kinase 1δ-IN-6 shows neuroprotective and anti-inflammatory properties both in vitro and in vivo. Casein kinase 1δ-IN-6 is a promising drug candidate and can be used for neurodegenerative diseases research.

HY-105222A

CHX-3107	Casein Kinase	Cancer
CHX-3107 is a *casein kinase* 2 inhibitor .

HY-W042648

4,5,6,7-Tetrabromo-1H-benzimidazole	Casein Kinase	Others
4,5,6,7-Tetrabromobenzimidazole is a selective and ATP competitive CK2 (casein kinase 2) inhibitor .

HY-P3748

Casein Kinase II Receptor Peptide	Casein Kinase	Others
Casein Kinase II Receptor Peptide is a substrate for casein kinase II with an K_m value of 500 µM. Casein Kinase II Substrate can be used for measure casein kinase II activity in crude enzyme preparations .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14393

Emodin 35+ Cited Publications Frangula emodin	Classification of Application Fields Polygonaceae Plants Endogenous metabolite Quinones Human Gut Microbiota Metabolites Microorganisms Rheum palmatum L. Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification Cancer	SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits *casein kinase-2* (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-14393R

Emodin (Standard) 35+ Cited Publications Frangula emodin (Standard)	Quinones Rheum palmatum L. Classification of Application Fields Polygonaceae Phenols Plants Disease Research Fields Source Classification Cancer	Reference Standards SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits *casein kinase-2* (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

Cat. No.	Product Name	Chemical Structure

HY-148233S

JNJ-6204
JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC₅₀=2.3 nM; CSNK1E IC₅₀=137 nM). JNJ-6204 shows good brain exposure .

HY-14393S

Emodin-d4

Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12879G

IWP-4	Wnt Casein Kinase	Cardiovascular Disease Neurological Disease Cancer
IWP-4 (GMP) is the GMP-grade form of IWP-4 (HY-12879). IWP-4 is a Wnt inhibitor with an IC₅₀ of 25 nM. IWP-4 specifically inhibits casein kinase 1δ/ε (CK1δ/ε), with an IC₅₀ of 1.06 μM against wild-type CK1δ, 1.02 μM against the CK1δ kinase domain, and 7.07 μM against CK1ε; it shows enhanced inhibitory activity against the M82F CK1δ mutant (IC₅₀ = 0.14 μM). IWP-4 is applicable to research related to cancer, Alzheimer's disease (AD), and heart failure .

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