1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase
  3. Casein Kinase II Inhibitor IV

Casein Kinase II Inhibitor IV 

Cat. No.: HY-111378 Purity: 98.08%
Handling Instructions

Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation.

For research use only. We do not sell to patients.

Casein Kinase II Inhibitor IV Chemical Structure

Casein Kinase II Inhibitor IV Chemical Structure

CAS No. : 863598-09-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
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10 mg USD 550 In-stock
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25 mg USD 1100 In-stock
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50 mg USD 1850 In-stock
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100 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation.

IC50 & Target

Target: Casein Kinase[1]

In Vitro

Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expressesloricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are again consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes[1].

Molecular Weight

429.47

Formula

C₂₄H₂₃N₅O₃

CAS No.

863598-09-8

SMILES

N#CCCC1=CC=CC(N2C=CC3=CN=C(NC4=CC(OC)=C(OC)C(OC)=C4)N=C32)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (582.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3285 mL 11.6423 mL 23.2845 mL
5 mM 0.4657 mL 2.3285 mL 4.6569 mL
10 mM 0.2328 mL 1.1642 mL 2.3285 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Kinase Assay
[1]

For reporter gene assays with transiently transfected cells, the cells are typically transfected in 150 mm-diam dishes when 30-40% confluent. A reporter plasmid, pGL3/3.7 kbp-IVLLuc plasmid, is transfected into the NHEKs. After 24 h, the transfected cells are plated into 96-well assay plates and treated with compound (Casein Kinase II Inhibitor IV) to a final concentration of 5 μM. After incubation for 2 d, reporter gene activity is measured using the Bright-Glo luciferase assay system[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 98.08%

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Casein Kinase II Inhibitor IV
Cat. No.:
HY-111378
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