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Results for "

MDA-MB-231+cell

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Akt (6) AMPK (1) Antibiotic (1) Apoptosis (37) Aurora Kinase (2) Autophagy (1) Bcl-2 Family (5) BRK (1) c-Met/HGFR (2) c-Myc (1) Cadherin (1) CaMK (1) Carbonic Anhydrase (1) Caspase (3) CDK (5) Cholinesterase (ChE) (1) Cyclin G-associated Kinase (GAK) (1) Discoidin Domain Receptor (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (6) Dopamine Receptor (1) Drug Derivative (4) DYRK (1) E1/E2/E3 Enzyme (1) EGFR (5) Endogenous Metabolite (2) Epigenetic Reader Domain (6) ERK (2) Estrogen Receptor/ERR (2) FAK (5) Ferroptosis (6) FGFR (1) Fluorescent Dye (1) Fungal (2) Glutaminase (1) HDAC (4) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (1) Histone Methyltransferase (6) HMG-CoA Reductase (HMGCR) (3) HSP (5) IAP (1) ICMT (1) Integrin (2) Isotope-Labeled Compounds (1) JAK (1) LIM Kinase (LIMK) (2) MDM-2/p53 (2) MEK (1) Microtubule/Tubulin (4) MMP (2) Monocarboxylate Transporter (1) mTOR (3) Necroptosis (2) NF-κB (1) Nuclear Hormone Receptor 4A/NR4A (1) Oxidative Phosphorylation (1) Oxysterol-binding Protein-related Protein (ORP) (1) PAK (4) PARP (6) Phosphatase (2) PI3K (3) PIN1 (1) PROTACs (15) Protein Arginine Deiminase (1) Ras (2) Reactive Oxygen Species (ROS) (7) Reference Standards (3) ROCK (2) ROR (1) Ser/Thr Kinase (1) SHP1 (1) Sialyltransferase (1) STAT (8) Survivin (1) TAM Receptor (1) TGF-β Receptor (1) Topoisomerase (6) VEGFR (2)
By Research Areas:	Cancer (120) Cardiovascular Disease (4) Infection (3) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (2)
Oligonucleotides:	Aptamers (2)

124

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139665

VB124 5+ Cited Publications	Monocarboxylate Transporter	Cardiovascular Disease
VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 can specifically inhibit lactate efflux with IC₅₀s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism .

HY-15518

LCL161 Maximum Cited Publications 41 Publications Verification	IAP	Cancer
LCL161 is a IAP inhibitor which inhibits XIAP in HEK293 cell and cIAP1 in MDA-MB-231 cell with IC₅₀s of 35 and 0.4 nM, respectively.

HY-109523

Cerivastatin sodium 2 Publications Verification	HMG-CoA Reductase (HMGCR) Ferroptosis	Cardiovascular Disease Cancer
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .

HY-108317

ABL127	Phosphatase	Cancer
ABL127 is a selective and covalent inhibitor of protein methylesterase 1 (PME-1) with IC₅₀s of 6.4 nM and 4.2 nM in HEK293T and MDA-MB-231 cells, respectively.

HY-13808

UNC 0631 5 Publications Verification	Histone Methyltransferase	Cancer
UNC 0631 is a potent histone methyltransferase G9a inhibitor with an IC₅₀ of 4 nM. UNC 0631 potently reduces H3K9me2 levels in MDA-MB-231 cells with an IC₅₀ of 25 nM .

HY-100753

STAT3-IN-1 10+ Cited Publications	STAT Apoptosis	Cancer
STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC₅₀ values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor cells apoptosis .

HY-145652

Narmafotinib 1 Publications Verification AMP-945
Narmafotinib (AMP-945) is an orally active inhibitor of the enzyme focal adhesion kinase (FAK, K_D=0.21 nM). Narmafotinib inhibits autophosphorylation of 397Y-FAK in MDA-MB-231 cells with an IC₅₀=7 nM and exhibits low general cellular toxicity (IC₅₀=2.7 μM, MDA-MB-231 cells). Narmafotinib can be used for anti-cancer study .

HY-112842

MBQ-167 10+ Cited Publications	Ras CDK	Cancer
MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC₅₀s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.

HY-173496

ST6GAL1-IN-1	Sialyltransferase Integrin VEGFR Akt	Cancer
ST6GAL1-IN-1 is an orally active selective ST6GAL1 inhibitor (IC₅₀ = 20 μM). ST6GAL1-IN-1 exhibits high antimetastatic potential, effectively inhibiting the migration of MDA-MB-231 cells at noncytotoxic concentrations. ST6GAL1-IN-1 can disrupt integrin sialylation in MDA-MB-231 cells. ST6GAL1-IN-1 inhibits tumor angiogenesis and cancer metastasis via the Integrin/VEGFR2-mediated signaling pathway. ST6GAL1-IN-1 effectively suppresses both tumor growth and cancer metastasis on the MDA-MB-231 xenograft model. ST6GAL1-IN-1 can be used for the study of Triple-negative breast cancer (TNBC) .

HY-13807

UNC0646 1 Publications Verification	Histone Methyltransferase	Cancer
UNC0646 is a potent and selective histone methyltransferase G9a inhibitor with an IC₅₀ of 6 nM. UNC0646 is also a potent GLP inhibitor (IC₅₀ <15 nM) and highly selective for G9a/GLP over SETD7, SUV39H2, SETD8 and PRMT3. UNC0646 reduces H3K9me2 levels in MDA-MB-231 cells with an IC₅₀ of 26 nM .

HY-13808R

UNC 0631 (Standard)	Reference Standards Histone Methyltransferase	Cancer
UNC 0631 (Standard) is the analytical standard of UNC 0631. This product is intended for research and analytical applications. UNC 0631 is a potent histone methyltransferase G9a inhibitor with an IC₅₀ of 4 nM. UNC 0631 potently reduces H3K9me2 levels in MDA-MB-231 cells with an IC₅₀ of 25 nM .

HY-146324

PROTAC eEF2K degrader-1	PROTACs Apoptosis CaMK	Cancer
PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation .

HY-15985

CTX-0294885 3 Publications Verification	Akt	Metabolic Disease Inflammation/Immunology Cancer
CTX-0294885 is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer .

HY-114979

Pyoluteorin	Antibiotic Fungal Apoptosis	Infection Cancer
Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus . Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer .

HY-100353

C12-Ceramide N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine	Endogenous Metabolite	Metabolic Disease Cancer
C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease .

HY-N6990

Anhydrosecoisolariciresinol	Others	Cancer
Anhydrosecoisolariciresinol is from the flower of Wedelia biflora, has anti-tumor activities . Anhydrosecoisolariciresinol decreases the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines .

HY-16191

ELR510444 1 Publications Verification	Microtubule/Tubulin Apoptosis	Cancer
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines.

HY-156273

HDAC/JAK/BRD4-IN-1	Apoptosis HDAC Epigenetic Reader Domain JAK	Cancer
HDAC/JAK/BRD4-IN-1(compound 25ap) is a potent HDAC/JAK/BRD4 triple inhibitor. HDAC/JAK/BRD4-IN-1 inhibit cell growth and induces apoptosis in MDA-MB-231 cells, and shows anticancer activity in vivo .

HY-110329

ML179	Nuclear Hormone Receptor 4A/NR4A	Cancer
ML179 (SR-1309) is a inverse LRH1/NR5A2 (Liver receptor homologue-1) agonist with IC₅₀ of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer .

HY-168929

SHP1 activator 1	SHP1 Fluorescent Dye Phosphatase STAT Apoptosis	Cancer
SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1(SHP1) with an EC₅₀ of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent .

HY-162352

SDU-071	Epigenetic Reader Domain Apoptosis	Cancer
SDU-071 is a potent and orally active inhibitor of BRD4-p53 inhibitor. SDU-071 inhibits MDA-MB-231 cells proliferation with an IC₅₀ of 10.5 μM. SDU-071 induces cell cycle arrest and apoptosis .

HY-129458

Cerivastatin	HMG-CoA Reductase (HMGCR) Ferroptosis	Cardiovascular Disease Cancer
Cerivastatin is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin reduces low-density lipoprotein cholesterol levels. Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .

HY-144699

ERRα antagonist-2	Estrogen Receptor/ERR	Cancer
ERRα antagonist-2 (Compound 11) is a potential ERRα (estrogen related receptor α) inverse agonist with an IC₅₀ of 0.80 μM. ERRα antagonist-2 suppresses the migration and invasion of the ER-negative MDA-MB-231 cell line. ERRα antagonist-2 inhibits breast cancer growth in vivo .

HY-161597

PROTAC DYRK2 degrader 1	PROTACs DYRK	Cancer
PROTAC DYRK2 degrader 1 is a DYRK2 PROTAC degrader with DC₅₀ values of 1.607 μM (MDA-MB-231 cells) and 3.265 μM (HeLa cells), respectively. PROTAC DYRK2 degrader 1 induces DYRK2 degradation via the ubiquitin-proteasome system. It is applicable to the research of triple-negative breast cancer and cervical cancer .

HY-114324A

rel-PROTAC PARP1 degrader	PROTACs PARP	Cancer
rel-PROTAC PARP1 degrader is the relative configuration of ROTAC PARP1 degrader (HY-114324). ROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC₅₀ of 6.12 μM.

HY-15985A

CTX-0294885 hydrochloride 3 Publications Verification	Akt	Metabolic Disease Inflammation/Immunology Cancer
CTX-0294885 hydrochloride is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 hydrochloride is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer .

HY-115507

NMac1	AMPK mTOR ERK Oxidative Phosphorylation Reactive Oxygen Species (ROS) Ras	Cancer
NMac1 is an orally active Nm23/NDPK activator. NMac1 directly binds to Nm23-H1 and activates the NDPK activity of recombinant Nm23-H1 with an EC₅₀ of 10.7 uM. NMac1 induces AMPK activation and inhibits mTOR and ERK, leading to mitochondrial OXPHOS dysregulation and suppressing mitochondrial ROS production, which in turn induces mitochondrial dysfunction in MDA-MB-231 cells. NMac1 inhibits Complex I activity and suppresses changes in morphology and actin cytoskeleton organization following Rac1 activation in MDA-MB-231 cells. NMac1 inhibits tumor invasion, migration and metastasis. NMac1 is useful for studying metastatic tumors, such as breast cancer. NMac1 can be isolated from the ginger cassumunar Roxb .

HY-175004

PBD dimer-4	ADC Payload DNA Alkylator/Crosslinker	Cancer
PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC₅₀: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types .

HY-175815

Apoptosis inducer 44	Apoptosis Bcl-2 Family Caspase MMP Cadherin	Cancer
Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating caspase-3 cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer .

HY-164521

PMMB-187	STAT	Cancer
PMMB-187 is a selective STAT3 inhibitor with an IC₅₀ value of 1.81 μM for MDA-MB-231 cells. PMMB-187 induces apoptosis (Apoptosis) in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity, nuclear translocation, and downstream target gene expression, while also reducing mitochondrial membrane potential, generating reactive oxygen species (ROS), and upregulating the expression levels of apoptosis-related proteins. PMMB-187 has potential applications in cancer research .

HY-W643128

Carlina oxide	Cholinesterase (ChE)	Infection
Carlina oxide is an AChE inhibitor and antioxidant that kills Culex pipiens larvae (LC50=1.39 μg/mL). Carlina oxide is cytotoxic to vertebrate cells, human dermis, HCT116 and MDA-MB231 cell lines .

HY-157151

iPRMT1	Histone Methyltransferase	Cancer
iPRMT1 is a potent and selective PRMT1 inhibitor for breast cancer research. iPRMT1 inhibits breast cancer cell growth in vitro and in vivo with EC₅₀ values of 90, 70, and 9 nM in MCF7, T47D, and MDA-MB-231 cells, respectively .

HY-178365

PAD-IN-4	Protein Arginine Deiminase	Inflammation/Immunology Cancer
PAD-IN-4 is a potent PAD inhibitor (PAD 1/4, IC₅₀ = 0.273/0.24 μM). PAD-IN-4 shows no significant cytotoxicity against A549 or MDA-MB-231 cells. PAD-IN-4 can be used for the study of cancer and autoimmune diseases .

HY-163845

YX862	PROTACs HDAC	Cancer
YX862 is a selective HDAC8 PROTAC degrader and induces the degradation of HDAC8 with maximum degradation ＞ 95% at 250 nM in MDA-MB-231 cells(Sturcture Note:(Blue: VHL E3 ligand (HY-112078), Black: linker；Pink: HDAC8 inhibitor (HY-163846)) .

HY-170946

WR-S-462	STAT Bcl-2 Family	Cancer
WR-S-462 is a STAT3 inhibitor. WR-S-462 effectively suppresses STAT3 phosphorylation and biological functions in vitro. WR-S-462 inhibits MDA-MB-231 cells with an IC₅₀ of 0.03 μM. WR-S-462 displays a strong binding affinity towards the STAT3 protein with a K_d of 58 nM. WR-S-462 inhibits the nuclear translocation of p-STAT3, selectively inhibits the expression of p-STAT3 ^Tyr705 and downstream target genes regulated by STAT3 in MDA-MB-231 cells such as Cyclin D1, Bcl-2, and Bcl-xl. WR-S-462 inhibits TNBC (triple-negative breast cancer) growth and metastasis .

HY-178956

KUNB106	HSP	Cancer
KUNB106 is a selective Hsp90β inhibitor with K_Ds of 91 nM and 38 μM against Hsp90β and Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231 cells, A549 and SKOV-3 cells. KUNB106 can be used for the study of triple negative breast cancer .

HY-174975

JY-21	PROTACs Epigenetic Reader Domain	Cancer
JY-21 is a BRD4 PROTAC degrader with a DC₅₀ of 3.797 μM. JY-21 has a potent anticancer activity against MDA-MB-231 cells . Pink: BRD4 ligand (HY-78695); Blue: E3 ligase ligand (HY-174994); Black: linker (HY-151862)

HY-175269

MGB1Y	DNA Alkylator/Crosslinker DNA/RNA Synthesis Topoisomerase	Cancer
MGB1Y is a noncovalent DNA minor groove binder (MGB). MGB1Y potently inhibits cancer cells proliferation and topoisomerase I activity. MGB1Y downregulates their breast cancer-related genes in MCF7 and MDA-MB-231 cells. MGB1Y has a broad-spectrum anticancer activity, such as breast cancer, colon cancer, and leukemia .

HY-164306

PROTAC PARP1 degrader-2	PROTACs PARP	Cancer
PROTAC PARP1 degrader-2 (Compound 72) is a PROTAC degrader for PARP with a DC₅₀<10 nM in MDA-MB-231 cell. PROTAC PARP1 degrader-2 inhibits the cell viability of MDA-MB-436 with an IC₅₀ <100 nM. (Blue: ligand for target protein (HY-160937); Pink: ligand for E3 ligase (HY-W998262))

HY-178132

Apoptosis inducer 46	Apoptosis NF-κB	Cancer
Apoptosis inducer 46 is an apoptosis inducer. Apoptosis inducer 46 exhibits potent and selective growth inhibitory effects on metastatic triple-negative breast cancer (TNBC) cells. Apoptosis inducer 46 induces G2/M phase cell cycle arrest and apoptotic cell death in MDA-MB-231 cells, and blocks NF-κB nuclear translocation. Apoptosis inducer 46 can be used for the study of TNBC .

HY-175656

MDI-117740	LIM Kinase (LIMK)	Neurological Disease Cancer
MDI-117740 is a dual LIMK1/2 inhibitor. MDI-117740 shows effective cellular target engagement with LIMK1 (pIC₅₀ = 6.73) and LIMK2 (pIC₅₀ = 7.18) in HEK293 cells. MDI-117740 exerts significant anti-migratory activity in MDA-MB-231 cells. MDI-117740 can be used for the study of cancers and neurodegenerative disorders .

HY-146786

ZMF-10	PAK Apoptosis	Cancer
ZMF-10 is a highly potent PAK1 inhibitor, with IC₅₀s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively. ZMF-10 can inhibit PAK1 activity to affect PAK1-regulated apoptosis, ER-Stress and migration in MDA-MB-231 cells. ZMF-10 can be used for researching anticancer .

HY-175179

LO-3-61	Epigenetic Reader Domain E1/E2/E3 Enzyme	Cancer
LO-3-61, a JQ-1 (HY-13030) analog bearing a truncated fumaramide handle, is a PROTAC (proteolysis-targeting chimeras)-like BRD4 degrader. LO-3-61 degrades both the long and short isoforms of BRD4 CUL4DcAr16-dependently in cells. LO-3-61 shows selectivity for BRD3 and BRD4 degradation in MDA-MB-231 cells .

HY-179054

Apoptosis inducer 51	Apoptosis Reactive Oxygen Species (ROS) DNA/RNA Synthesis	Cancer
Apoptosis inducer 51 (Compound 5d) is an apoptosis inducer. Apoptosis inducer 51 exhibits strong inhibitory activity against MDA-MB-231 cells. Apoptosis inducer 51 inhibits cell invasion and migration, induces G2/M phase cell cycle arrest and cell apoptosis. Apoptosis inducer 51 causes DNA damage, ROS burst and mitochondrial membrane potential (MMP) collapse. Apoptosis inducer 51 can be used for the study of triple-negative breast cancer.

HY-146203

FAK inhibitor 6	FAK	Cancer
Compound 26F not only optimized the effective inhibitory enzyme (ic₅₀= 28.2 nm), but also showed relatively less cytotoxicity (ic₅₀= 3.32 μ M) And induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in g0/g1 phase.

HY-156026

FAK-IN-11	FAK	Cancer
FAK-IN-11 (Compound 4l) is a FAK inhibitor. FAK-IN-11 binds to the ATP binding pocket of FAK, and inhibits phosphorylation of FAK protein. FAK-IN-11 shows cytotoxic activity against the MDA-MB-231 cells with an IC₅₀ of 13.73? μM. FAK-IN-11 induces non-apoptotic cell death in MDA-MB-231 cells .

HY-125958

AA9	Glutaminase	Cancer
AA9 is a potent Transglutaminase 2 (TG2) inhibitor. AA9 strongly impacts HIF-mediated hypoxia in MDA-MB-231 cells .

HY-146511

Anticancer agent 41	Others	Cancer
Anticancer agent 41 is a potent anticancer agent, shows a potent antitumor activity against MDA-MB-231 cell with an IC50 of 3.99 μM[1].

HY-158388

Anticancer agent 215	Topoisomerase	Cancer
Anticancer agent 215 (1) is a Camptothecin compound, with IC₅₀ values of 5.2 nM and 8.2 nM in MCF-7 cells and MDA-MB-231 cells, respectively .

HY-158389

Anticancer agent 216	Topoisomerase	Cancer
Anticancer agent 216 (34A) is a Camptothecin compound, with IC₅₀ values of 9.6 nM and 11.6 nM in MCF-7 cells and MDA-MB-231 cells, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8146

Bruceantinol	Infection Triterpenes Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Source Classification Cancer	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .

HY-N6990

Anhydrosecoisolariciresinol	other families Classification of Application Fields Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Others
Anhydrosecoisolariciresinol is from the flower of Wedelia biflora, has anti-tumor activities . Anhydrosecoisolariciresinol decreases the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines .

HY-W643128

Carlina oxide	Natural Products Carlina acaulis L. Plants Compositae Source Classification	Cholinesterase (ChE)
Carlina oxide is an AChE inhibitor and antioxidant that kills Culex pipiens larvae (LC50=1.39 μg/mL). Carlina oxide is cytotoxic to vertebrate cells, human dermis, HCT116 and MDA-MB231 cell lines .

HY-N13163

2-Epitripdiolide	Terpenoids Celastraceae Diterpenoids Tripterygium wilfordii Hook. f. Plants Source Classification	Others
2-Epitripdiolide is a diterpenoid compound derived from Tripterygium hypoglaucum with significant antitumor activity. Its IC₅₀ values against A549, KB, KBvin, and MDA-MB-231 cells are 1.34, 0.4, 4.4, and 1.2 nM, respectively .

HY-W667666

Anthragallol 1,2-dimethyl ether	Quinones Anthraquinones Hedyotis puberula (G. Don) Arn. Rubiaceae Plants Source Classification	Others
Anthragallol 1,2-dimethyl ether (compound 11) can be isolated from O. umbellata. Anthragallol 1,2-dimethyl ether has cytotoxicity, with IC₅₀ values of 5.9 and 8.8 μg/ml against A549 cells and MDA-MB-231 cells, respectively .

Cat. No.	Product Name	Chemical Structure

HY-109523S

Cerivastatin-d3 sodium

Cerivastatin-d₃ sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .

Cat. No.	Product Name		Classification

HY-160050

CD63-1 aptamer sodium		Aptamers
CD63-1 aptamer sodium is a high-affinity and specific DNA aptamer targeting the CD63 protein (Kd: 38.71 nM). CD63-1 aptamer sodium efficiently binds to CD63-positive cells, including breast cancer MDA-MB-231 cells and CD63-overexpressing HEK293T cells, with moderate binding affinity (Kd~100 nM) as assessed by flow cytometry .

HY-160051

CD63-2 aptamer sodium		Aptamers
CD63-2 aptamer sodium is a high-affinity and specific DNA aptamer targeting the CD63 protein (Kd: 78.43 nM). CD63-1 aptamer sodium efficiently binds to CD63-positive cells, including breast cancer MDA-MB-231 cells and CD63-overexpressing HEK293T cells, with moderate binding affinity (Kd~100 nM) as assessed by flow cytometry .

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