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Cat. No.: HY-156296

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CDK9-Cyclin T1 PPI-IN-1

CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective CDK9-Cyclin T1 protein-protein interaction (PPI) inhibitor. CDK9-Cyclin T1 PPI-IN-1 inhibits cell proliferation in TNBC MDA-MB-231 cells (IC₅₀: 0.044 μM), and induces apoptosis. CDK9-Cyclin T1 PPI-IN-1 inhibits CDK9 transcription activity, reduces the phosphorylation of RNA Pol II CTD ser2. CDK9-Cyclin T1 PPI-IN-1 inhibits tumor growth in a TNBC 4T1 mouse model.

For research use only. We do not sell to patients.

CAS No.: 2995336-58-6
Formula: C₂₃H₂₄N₄O₃
Molecular Weight:404.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CDK9-Cyclin T1 PPI-IN-1 Chemical Structure

CAS No.: 2995336-58-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	0.441 μM Compound: B19	Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
A549	IC₅₀	2.305 μM Compound: B19	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
BT-549	IC₅₀	0.147 μM Compound: B19	Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
HEK-293T	IC₅₀	>0.8 μM Compound: 6; B19	Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38564299]
HeLa	IC₅₀	0.158 μM Compound: B19	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
HepG2	IC₅₀	0.392 μM Compound: B19	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
HK-2	IC₅₀	0.481 μM Compound: B19	Cytotoxicity against HK-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against HK-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
Hs-578T	IC₅₀	0.131 μM Compound: B19	Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
L02	IC₅₀	>0.8 μM Compound: 6; B19	Antiproliferative activity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38564299]
L02	IC₅₀	0.756 μM Compound: B19	Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
MCF-10A	IC₅₀	0.498 μM Compound: B19	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
MDA-MB-231	IC₅₀	0.044 μM Compound: B19	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
MDA-MB-231	IC₅₀	1.61 μM Compound: B19	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 37837671]
MDA-MB-231	IC₅₀	201 nM Compound: B19	Antiproliferative activity against human MDA-MB-231 cells transfected with shCDK9 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells transfected with shCDK9 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]
MRC5	IC₅₀	0.335 μM Compound: B19	Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37837671]

Chemical Information

CAS No. 2995336-58-6
Molecular Weight 404.46
Formula C₂₃H₂₄N₄O₃
SMILES

COC1=CC=C(C=C1)C(NC2=CC(C3=CC(N4CCC(CC4)O)=NC=C3)=CC=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gao G, et al. Design, synthesis, and biological evaluation of novel 4,4'-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer. Eur J Med Chem. 2023 Oct 6;261:115858. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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CDK9-Cyclin T1 PPI-IN-1

All CDK Isoforms