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Cat. No.: HY-155039

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Antitumor agent-105

Antitumor agent-105 (Compound 37) is an antitumor agent. Antitumor agent-105 has antitumor activity against A549, H1299, H460, HCT116, MDA-MB-231 cells, with IC₅₀ values of 6.7, 8.3, 4.3, 4.4, 6.7 μM respectively.

For research use only. We do not sell to patients.

Formula: C₂₆H₃₀N₂O₄
Molecular Weight:434.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Antitumor agent-105 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.7 μM Compound: 37	Antitumor activity against human A549 cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human A549 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37271378]
HCT-116	IC₅₀	4.4 μM Compound: 37	Antitumor activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37271378]
Hep 3B2	IC₅₀	>10 μM Compound: 37	Antitumor activity against human Hep3B cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human Hep3B cells assessed as inhibition of cell growth by MTT assay	[PMID: 37271378]
MDA-MB-231	IC₅₀	6.7 μM Compound: 37	Antitumor activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37271378]
NCI-H1299	IC₅₀	8.3 μM Compound: 37	Antitumor activity against human NCI-H1299 cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human NCI-H1299 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37271378]
NCI-H460	IC₅₀	4.3 μM Compound: 37	Antitumor activity against human NCI-H460 cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human NCI-H460 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37271378]

Chemical Information

Molecular Weight 434.53
Formula C₂₆H₃₀N₂O₄
SMILES

[H][C@]([C@@]1([H])O2)(COC3=C1C=C4C(OC(C)(C)C=C4)=C3)C5=C2C=C(C=C5)OCCN6CCNCC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang G, et al. Syntheses and antitumor activities of neorautenol and shinpterocarpin analogs. Bioorg Med Chem Lett. 2023 Jul 15;91:129353. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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