country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-175544

Copy Link Print Information

anti-TNBC agent-10

anti-TNBC agent-10 is an anti-TNBC agent. anti-TNBC agent-10 shows potent anti-TNBC activity against BT549 cells (IC₅₀ = 0.018 μM) and maintains activity against MDA-MB-231 cells (IC₅₀ = 4.16 μM). anti-TNBC agent-10 9 demonstrates significant anti-tumor efficacy in mice bearing subcutaneous MDA-MB-231 TNBC xenografts. anti-TNBC agent-10 can be used for the study of triple-negative breast cancer (TNBC).

For research use only. We do not sell to patients.

CAS No.: 2923722-02-3
Formula: C₁₁H₁₁F₄N₅O₃
Molecular Weight:337.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

anti-TNBC agent-10 Chemical Structure

CAS No.: 2923722-02-3

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

anti-TNBC agent-10 9 (Analog 9) (25 mg/kg, intraperitoneal injection, quaque 1 die x 5 (Q1Dx5) for 2 weeks) demonstrates significant anti-tumor efficacy in athymic nude mice bearing subcutaneous MDA-MB-231 TNBC xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MDA-MB-231 TNBC cells were subcutaneously implanted into the right flanks of athymic nude mice to establish a subcutaneous TNBC xenograft model^[1]
Dosage:

25 mg/kg
Administration:

intraperitoneal injection, Q1Dx5 for 2 weeks
Result:

Achieved significant tumor growth inhibition.

Chemical Information

CAS No. 2923722-02-3
Molecular Weight 337.23
Formula C₁₁H₁₁F₄N₅O₃
SMILES

F[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(N=C(C(F)(F)F)N=C3N)=C3N=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Moukha-Chafiq O,et al. Discovery of a novel non-toxic analog of clofarabine for the treatment of triple-negative breast cancer. Bioorg Med Chem Lett. 2025 Dec 1;128:130349. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote