MDI-117740
MDI-117740 is a dual LIMK1/2 inhibitor. MDI-117740 shows effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells. MDI-117740 exerts significant anti-migratory activity in MDA-MB-231 cells. MDI-117740 can be used for the study of cancers and neurodegenerative disorders.
For research use only. We do not sell to patients.
- Formula: C24H24N4O2
- Molecular Weight:400.47
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
LIMK1 7.80 (pKd) |
LIMK2 7.12 (pKd) |
LIMK1 6.73 (pIC50) |
LIMK2 7.18 (pIC50) |
MDI-117740 exhibits potent binding affinity to LIMK1 (pKd = 7.80) and LIMK2 (pKd = 7.12) as well as effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells[1].
MDI-117740 (2 h) potently inhibits cofilin phosphorylation (p-cofilin) in SH-SY5Y cells, with a pIC50 value of 6.89[1].
MDI-117740 (0.25-3 μM, 48 h) exerts significant anti-migratory activity in MDA-MB-231 cells via wound healing assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 400.47
-
Formula C24H24N4O2
-
SMILES
O=C(C1=C(CCN2[C@H](C3CC3)C4=CC=CC=C4)C(C2=O)=NN1CC5=CC=CC=C5)N
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz