3107269-84-8
Chemical Structure
MDI-117740
- CAS No.: 3107269-84-8
- Formula:C24H24N4O2
- Molecular Weight:400.47
IUPAC Name: (R)-2-benzyl-6-(cyclopropyl(phenyl)methyl)-7-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxamide
InChIKey: KGBMUNOIXNJOLJ-NRFANRHFSA-N
SMILES: O=C(C1=C(CCN2[C@H](C3CC3)C4=CC=CC=C4)C(C2=O)=NN1CC5=CC=CC=C5)N
Biological Activity: MDI-117740 is a dual LIMK1/2 inhibitor. MDI-117740 shows effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells. MDI-117740 exerts significant anti-migratory activity in MDA-MB-231 cells. MDI-117740 can be used for the study of cancers and neurodegenerative disorders[1].
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MDI-117740 | MDI-117740 is a dual LIMK1/2 inhibitor. MDI-117740 shows effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells. MDI-117740 exerts significant anti-migratory activity in MDA-MB-231 cells. MDI-117740 can be used for the study of cancers and neurodegenerative disorders. | |||||||||||||||||||||
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Keywords
