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Cat. No.: HY-156077

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anti-TNBC agent-2

anti-TNBC agent-2 (3j) an anti-Triple negative breast cancer (TNBC) purine derivative. anti-TNBC agent-2 induces MDA-MB-231 cells apoptosis, and inhibits its migration and angiogenesis. anti-TNBC agent-2 inhibits tumor growth and metastasis and reduces the expression of Ki67 and CD31 protein in TNBC xenograft models. anti-TNBC agent-2 can be used for Triple negative breast cancer (TNBC) research.

For research use only. We do not sell to patients.

CAS No.: 2422001-22-5
Formula: C₂₈H₃₇ClFN₇O
Molecular Weight:542.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

anti-TNBC agent-2 Chemical Structure

CAS No.: 2422001-22-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.12 μM Compound: 3j	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
HCT-116	IC₅₀	0.34 μM Compound: 3j	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
HEK293	IC₅₀	4.32 μM Compound: 3j	Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
HepG2	IC₅₀	1.68 μM Compound: 3j	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
HT-29	IC₅₀	4.16 μM Compound: 3j	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
HUVEC	IC₅₀	4.26 μM Compound: 3j	Antiproliferative activity against human HUVEC cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human HUVEC cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
K562	IC₅₀	0.32 μM Compound: 3j	Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
MCF7	IC₅₀	0.43 μM Compound: 3j	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
MDA-MB-231	IC₅₀	3.15 μM Compound: 3j	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
MDA-MB-468	IC₅₀	2.82 μM Compound: 3j	Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
MGC-803	IC₅₀	3.89 μM Compound: 3j	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
NCI-H1299	IC₅₀	4.28 μM Compound: 3j	Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
PC-3	IC₅₀	2.43 μM Compound: 3j	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]

Chemical Information

CAS No. 2422001-22-5
Molecular Weight 542.09
Formula C₂₈H₃₇ClFN₇O
SMILES

FC1=CC=C(C=C1Cl)CNC2=C3N=CN(C3=NC(N4CCC(CC4)C5CCN(CC5)CCO)=N2)CC6CC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Q, et al. Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer. Eur J Med Chem. 2023 Sep 7;261:115797. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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anti-TNBC agent-2

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

anti-TNBC agent-2 Related Classifications

HY-156077 Related Classifications