LASSBio-2389

Cat. No.: HY-181583: Data Sheet Handling Instructions
FAQs
Technical Support

LASSBio-2389 is a selective ROCK2 inhibitor with an IC₅₀ of 0.051 μM and an IC₅₀ of 1.143 μM against ROCK1. LASSBio-2389 reduces the viability of MDA-MB-231 cells and inhibits cell migration. LASSBio-2389 is applicable to the research of triple-negative breast cancer.

For research use only. We do not sell to patients.

LASSBio-2389 Chemical Structure

CAS No. : 2671377-38-9

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All ROCK Isoform Specific Products:

View All Isoforms

ROCK ROCK1 ROCK2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

ROCK1

1.143 μM (IC₅₀)

ROCK2

0.051 μM (IC₅₀)

In Vitro

LASSBio-2389 exhibits high passive permeability in gastrointestinal tract models, but shows no permeability in blood-brain barrier models^[1].
LASSBio-2389 (30 μM; 24 h) reduces the viability of MDA-MB-231 cells^[1].
LASSBio-2389 (0.1-100 μM; 24 h) potently inhibits the migration of MDA-MB-231 cells at concentrations as low as 0.1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-231 triple-negative breast cancer cells
Concentration:	30 μM
Incubation Time:	24 h
Result:	Reduced MDA-MB-231 cell viability by 26.2% (73.8% viability relative to vehicle control).

Molecular Weight

354.36

Formula

C₁₈H₁₈N₄O₄

CAS No.

2671377-38-9

SMILES

O=C(C1=CC(OC)=C(OC)C(OC)=C1)N/N=C/C2=CC(C=NN3)=C3C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pinheiro P S M, et al. Discovery of N-Acylhydrazone Derivatives as ROCK Inhibitors: A Journey from Virtual Screening and Structure-Based De Novo Design to the Identification of ROCK2 Selective Inhibitors and Beyond. ACS Bio & Med Chem Au, 2026.

LASSBio-2389 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LASSBio-23892671377-38-9LASSBio2389LASSBio 2389ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKPAMPA-GIT modelmigration inhibitorROCK1triple-negative breast cancerROCK2MDA-MB-231 cellInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *