LASSBio-2389
LASSBio-2389 is a selective ROCK2 inhibitor with an IC50 of 0.051 μM and an IC50 of 1.143 μM against ROCK1. LASSBio-2389 reduces the viability of MDA-MB-231 cells and inhibits cell migration. LASSBio-2389 is applicable to the research of triple-negative breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2671377-38-9
- Formula: C18H18N4O4
- Molecular Weight:354.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ROCK1 1.143 μM (IC50) |
ROCK2 0.051 μM (IC50) |
LASSBio-2389 exhibits high passive permeability in gastrointestinal tract models, but shows no permeability in blood-brain barrier models[1].
LASSBio-2389 (30 μM; 24 h) reduces the viability of MDA-MB-231 cells[1].
LASSBio-2389 (0.1-100 μM; 24 h) potently inhibits the migration of MDA-MB-231 cells at concentrations as low as 0.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 triple-negative breast cancer cells
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Concentration:30 μM
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Incubation Time:24 h
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Result:Reduced MDA-MB-231 cell viability by 26.2% (73.8% viability relative to vehicle control).
Chemical Information
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CAS No. 2671377-38-9
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Molecular Weight 354.36
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Formula C18H18N4O4
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SMILES
O=C(C1=CC(OC)=C(OC)C(OC)=C1)N/N=C/C2=CC(C=NN3)=C3C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LASSBio-2389 Related Classifications
HY-181583 Related Classifications
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