2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. RIDR-PI-103

RIDR-PI-103 is a reactive oxygen species (ROS)-induced drug release prodrug with a self-cyclizing moiety linked to a pan-PI3K inhibitor (PI-103).

For research use only. We do not sell to patients.

RIDR-PI-103 Chemical Structure

RIDR-PI-103 Chemical Structure

CAS No. : 2581114-71-6

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1 mg USD 200 In-stock
5 mg USD 580 In-stock
10 mg USD 1050 In-stock
25 mg USD 2250 In-stock
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Based on 1 publication(s) in Google Scholar

RIDR-PI-103 Related Antibodies

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Description

RIDR-PI-103 is a reactive oxygen species (ROS)-induced drug release prodrug with a self-cyclizing moiety linked to a pan-PI3K inhibitor (PI-103). Doxorubicin and RIDR-PI-103 shows a synergistic effect in MDA-MB-361 and MDA-MB-231 cells to inhibit cancer cell proliferation[1][2].

Molecular Weight

511.53

Formula

C27H25N7O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(CN)NC1=CC(N)=CC=C1OC2=CC=CC(C3=NC4=C(C(N5CCOCC5)=N3)OC6=NC=CC=C64)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (195.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9549 mL 9.7746 mL 19.5492 mL
5 mM 0.3910 mL 1.9549 mL 3.9098 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9549 mL 9.7746 mL 19.5492 mL 48.8730 mL
5 mM 0.3910 mL 1.9549 mL 3.9098 mL 9.7746 mL
10 mM 0.1955 mL 0.9775 mL 1.9549 mL 4.8873 mL
15 mM 0.1303 mL 0.6516 mL 1.3033 mL 3.2582 mL
20 mM 0.0977 mL 0.4887 mL 0.9775 mL 2.4436 mL
25 mM 0.0782 mL 0.3910 mL 0.7820 mL 1.9549 mL
30 mM 0.0652 mL 0.3258 mL 0.6516 mL 1.6291 mL
40 mM 0.0489 mL 0.2444 mL 0.4887 mL 1.2218 mL
50 mM 0.0391 mL 0.1955 mL 0.3910 mL 0.9775 mL
60 mM 0.0326 mL 0.1629 mL 0.3258 mL 0.8145 mL
80 mM 0.0244 mL 0.1222 mL 0.2444 mL 0.6109 mL
100 mM 0.0195 mL 0.0977 mL 0.1955 mL 0.4887 mL
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RIDR-PI-103 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIDR-PI-1032581114-71-6Reactive Oxygen SpeciesROSMDA-MB-361MDA-MB-231 cellscancer cell proliferationprodrugbreast cancerInhibitorinhibitorinhibit

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