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Cat. No.: HY-149033

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Kobusine derivative-2

Kobusine derivative-2, a kobusine derivative, has antiproliferative activity against cancer cells. Kobusine derivative-2 can induce the arrest of MDA-MB-231 cells in the sub-G1 phase. Anticancer activity.

For research use only. We do not sell to patients.

Formula: C₃₆H₃₅Cl₄NO₄
Molecular Weight:687.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Kobusine derivative-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Kobusine derivative-2 (compound 25) (0-20 μM; 72 h) has antiproliferative activity against cancer cell lines A549, MDA-MB-231, MCF-7, KB and KB-VIN^[1].
Kobusine derivative-2 (12 or 24 h; 13.3 μM) arrests MDA-MB-231 cells at the sub-G1 phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

A549, MDA-MB-231, MCF-7, KB and KB-VIN
Concentration:

0-20 μM
Incubation Time:

72 h
Result:

Exhibited antiproliferative activity against cancer cell lines A549, MDA-MB-231, MCF-7, KB and KB-VIN with IC₅₀s of 4.4 μM, 4.2 μM, 4.5 μM, 4.5 μM and 4.6 μM, respectively.

Cell Cycle Analysis^[1]

Cell Line:

MDA-MB-231
Concentration:

12 or 24 h
Incubation Time:

13.3 μM (3-fold of IC₅₀)
Result:

Decreased numbers of cells in S and G2/M phases, resulting in accumulation of sub-G1.

Chemical Information

Molecular Weight 687.48
Formula C₃₆H₃₅Cl₄NO₄
SMILES

C[C@]12[C@]3([H])[C@]4(CCC1)[C@@](N(C2)[C@H]3C5)([H])[C@@H](C[C@@H]6C7=C)[C@@]5([C@@H]7OC(C8=CC=C(C(Cl)Cl)C=C8)=O)[C@@]4([H])[C@H]6OC(C9=CC=C(C(Cl)Cl)C=C9)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Koji Wada, et al. Discovery of C20-Diterpenoid Alkaloid Kobusine Derivatives Exhibiting Sub-G1 Inducing Activity. American Chemical Society. 2022

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

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100 mg

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