Cath-L-dBET1
Cath-L-dBET1 is a PROTAC degrader targeting BRD4. Cath-L-dBET1 has an IC50 value of 2.8 μM in MDA-MB-231 cells. Cath-L-dBET1 can be activated by cathepsin L (Cath-L) and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study.
(Pink: BRD4 ligand (HY-178094); Blue: Cereblon ligand (HY-103597); Black: linker (HY-178092)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C58H66ClN11O11S
- Peso molecular:1160.73
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
Descripciòn
Chemical Information
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Peso molecular 1160.73
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Fòrmula C58H66ClN11O11S
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SMILES
CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(NCCCCN(C(COC4=C5C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)=CC=C4)=O)CC7=CC=C(NC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(C)=O)=O)C=C7)=O)=C(S1)N8C3=NN=C8C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cath-L-dBET1 Related Classifications
HY-173257 Related Classifications
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