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Cat. No.: HY-161257

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CDC20-IN-1

CDC20-IN-1 (Compound E1) is a specific inhibitor of CDC20 and can be used in triple-negative breast cancer research. CDC20-IN-1 can induce autophagy in cancer cells and inhibit MDA-MB-231 cell proliferation, with an IC₅₀ value of 1.43 μM.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₂Cl₃N₇O₄
Molecular Weight:518.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CDC20-IN-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.47 μM Compound: E1	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38364716]
L02	IC₅₀	14.66 μM Compound: E1	Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38364716]
MCF7	IC₅₀	3.27 μM Compound: E1	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38364716]
MDA-MB-231	IC₅₀	1.43 μM Compound: E1	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38364716]
MDA-MB-468	IC₅₀	7.24 μM Compound: E1	Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38364716]

Chemical Information

Molecular Weight 518.78
Formula C₁₉H₂₂Cl₃N₇O₄
SMILES

O=C(CC)NC(C(Cl)(Cl)Cl)N(C=N1)C2=C1C(NC3=CC(OC)=C(OC)C(OC)=C3)=NC(N)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao SF, et al. Design, synthesis and biological evaluation of CDC20 inhibitors for treatment of triple-negative breast cancer. Eur J Med Chem. 2024 Feb 8;268:116204. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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