2. Apoptosis
  3. Apoptosis
  4. JMX0293

JMX0293 is an O-alkylamino-tethered salicylamide derivative compound. JMX0293 maintains good potency against MDA-MB-231 cell line (IC50 = 3.38 μM) while exhibiting very low toxicity against human non-tumorigenic breast epithelial cell line MCF-10A (IC50> 60 μM). JMX0293 inhibits STAT3 phosphorylation and contribute to apoptosis in TNBC MDA-MB-231 cells. JMX0293 significantly suppresses MDA-MB-231 xenograft tumor growth in vivo without significant toxicity.

For research use only. We do not sell to patients.

JMX0293 Chemical Structure

JMX0293 Chemical Structure

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Description

JMX0293 is an O-alkylamino-tethered salicylamide derivative compound. JMX0293 maintains good potency against MDA-MB-231 cell line (IC50 = 3.38 μM) while exhibiting very low toxicity against human non-tumorigenic breast epithelial cell line MCF-10A (IC50> 60 μM). JMX0293 inhibits STAT3 phosphorylation and contribute to apoptosis in TNBC MDA-MB-231 cells. JMX0293 significantly suppresses MDA-MB-231 xenograft tumor growth in vivo without significant toxicity[1].

Molecular Weight

569.43

Formula

C25H30Cl2N4O7
SMILES

CC([C@H](NC(C1=C(C=CC(Cl)=C1)OCCNC(OC(C)(C)C)=O)=O)C(NC2=C(C=C(C=C2)[N+]([O-])=O)Cl)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JMX0293 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMX0293JMX 0293JMX-0293ApoptosisO-alkylamino-tetheredsalicylamidetoxicityapoptosistumorInhibitorinhibitorinhibit

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