1. Apoptosis MAPK/ERK Pathway
  2. Apoptosis MEK
  3. MEK-IN-5

MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-dependent and time-dependent manner. MEK-IN-5 induces apoptosis in MDA-MB-231 cells.

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MEK-IN-5 Chemical Structure

MEK-IN-5 Chemical Structure

CAS No. : 2417022-06-9

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Description

MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-dependent and time-dependent manner. MEK-IN-5 induces apoptosis in MDA-MB-231 cells[1].

In Vitro

MEK-IN-5 (compound 18h) shows anti-proliferation activities for different tumor cells and low toxicity for normal cells[1].
MEK-IN-5 (0.1, 1, 10 µM; 1, 2, 4, 6 h) decreases the expression level of pMEK and pERK in a dose-dependent and time-dependent manner[1].
MEK-IN-5 (1, 10 µM; 24 h) induces apoptosis in MDA-MB-231 cells[1].
MEK-IN-5 (100 µM; 2h) significantly induce NO release in HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HCT116, A549, Vero, HL7702 cells
Concentration:
Incubation Time:
Result: Showed anti-proliferation activities in MDA-MB-231, HCT116, A549, Vero, HL7702 cells with IC50s of 0.034, 0.64, 1.35, 21.07, 5.62 µM, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 1, 10 µM
Incubation Time: 1, 2, 4, 6 h
Result: Decreased the expression level of pMEK and pERK in a dose-dependent and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1, 10 µM
Incubation Time: 24 h
Result: Induced apoptosis in MDA-MB-231 cells.
Molecular Weight

674.67

Formula

C29H27FN4O10S2

CAS No.
SMILES

O=C1OC2=C(C(C)=C1CC3=C(F)C(NS(=O)(NC)=O)=CC=C3)C=CC(OCCCOC4=NO[N+]([O-])=C4S(=O)(C5=CC=CC=C5)=O)=C2

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Purity & Documentation
References
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MEK-IN-5 Related Classifications

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MEK-IN-5
Cat. No.:
HY-143468
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