PBD dimer-4
PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types.
For research use only. We do not sell to patients.
- CAS No.: 1821339-88-1
- Formula: C31H36N4O8
- Molecular Weight:592.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1821339-88-1
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Molecular Weight 592.64
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Formula C31H36N4O8
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SMILES
[H][C@]12C=NC3=CC(OC)=C(C=C3C(N1CC[C@@H]2OCCCO[C@H]4CCN5C(C6=CC(OC)=C(C=C6N=C[C@]45[H])OC)=O)=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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