1821339-88-1
Chemical Structure
PBD dimer-4
- CAS No.: 1821339-88-1
- Formula:C31H36N4O8
- Molecular Weight:592.64
IUPAC Name: (1S,1'S,11aR,11a'R)-1,1'-(propane-1,3-diylbis(oxy))bis(7,8-dimethoxy-1,2,3,11a-tetrahydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one)
InChIKey: YADKAJDWESMLLP-NGSHPTGOSA-N
SMILES: [H][C@]12C=NC3=CC(OC)=C(C=C3C(N1CC[C@@H]2OCCCO[C@H]4CCN5C(C6=CC(OC)=C(C=C6N=C[C@]45[H])OC)=O)=O)OC
Biological Activity: PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types[1].
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PBD dimer-4 | PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types. | |||||||||||||||||||||
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