Aurora A inhibitor 2
Aurora A inhibitor 2 (Compound 16h) is a potent Aurora A kinase inhibitor with an IC50 of 21.94 nM. Aurora A inhibitor 2 induces caspase-dependent apoptosis in MDA-MB-231 cells.
For research use only. We do not sell to patients.
- CAS No.: 2412144-74-0
- Formula: C24H26N6O3
- Molecular Weight:446.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Aurora Kinase Isoforms
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Biological Activity
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Aurora A 21.94 nM (IC50) |
Aurora B 273.18 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
0.38 μM
Compound: 16h
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32058239] |
| PC-3 | IC50 |
1.09 μM
Compound: 16h
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Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32058239] |
| SH-SY5Y | IC50 |
0.77 μM
Compound: 16h
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Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32058239] |
Aurora A inhibitor 2 (Compound 16h) (0-20 µM, 48 h) shows potent antiproliferative activity against various human cancer cells, and inhibits colony formation[1].
Aurora A inhibitor 2 (0-4 µM, 24 h) inhibits the expression of phosphorylation of Aurora A and Histone H3 in a dose-dependent manner, and induces G2/M cell cycle arrest [1].
Aurora A inhibitor 2 (0-4 µM, 48 h) induces obvious apoptosis in MDA-MB-231 cells in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Breast cancer MDA-MB231, prostate cancer PC3, and neuroblastoma SH-SY5Y cells
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Concentration:0-20 µM
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Incubation Time:48 h
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Result:Displayed potent antiproliferative activity with IC50 values of 0.38 ± 0.08, 1.09 ± 0.24, and 0.77 ± 0.12 µM against MDA-MB-231, PC3, and SH-SY5Y cells.
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Cell Line:MDAMB-231
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Concentration:1, 2, and 4 µM
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Incubation Time:24 h
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Result:A dose-dependent and significant reduction in the phosphorylation of Aurora A and Histone H3 was observed. Significantly increased the levels of cleaved caspase 3/9 and cleaved-PARP.
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Cell Line:MDAMB-231
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Concentration:1, 2, and 4 µM
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Incubation Time:24 h
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Result:Dose-dependently increased the and population of cells in the G2/M phase.
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Cell Line:MDAMB-231
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Concentration:1, 2, and 4 µM
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Incubation Time:48 h
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Result:Induced obvious apoptosis in a concentration-dependent manner.
Chemical Information
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CAS No. 2412144-74-0
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Molecular Weight 446.50
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Formula C24H26N6O3
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SMILES
CCC(NC1=NC2=CC=C(C3=CC4=C(N=CN(CCN5CCOCC5)C4=O)C=C3)C=C2N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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