Anticancer agent 41
Anticancer agent 41 is a potent anticancer agent, shows a potent antitumor activity against MDA-MB-231 cell with an IC50 of 3.99 μM[1].
For research use only. We do not sell to patients.
- CAS No.: 1394077-28-1
- Formula: C25H18Br2N2O3
- Molecular Weight:554.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 3.99 μM (anticancer in MDA-MB-231 cell)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
>25 μg/mL
Compound: 3h
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Antiproliferative activity against human MCF7 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells after 48 hrs by CCK-8 assay
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[PMID: 22658083] |
| MDA-MB-231 | IC50 |
>10 μg/mL
Compound: 3h
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Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK-8 assay
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[PMID: 22658083] |
Chemical Information
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CAS No. 1394077-28-1
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Molecular Weight 554.23
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Formula C25H18Br2N2O3
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SMILES
COC1=CC2=C(NC(C)=C2C3=C(C(C(C4=C(NC5=C4C=CC=C5)C)=C(C3=O)Br)=O)Br)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 41 Related Classifications
HY-146511 Related Classifications
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