HDAC-IN-46
HDAC-IN-46 (compound 12c) is a potent HDAC inhibitor with an IC50 value of 0.21 μM and 0.021 μM for HDAC1 and HDAC6, respectively. HDAC-IN-46 upregulates p-p38, and downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells. HDAC-IN-46 induces significant G2 phase arrest and apoptosis. HDAC-IN-46 can be used for researching triple-negative breast cancer (TNBC).
For research use only. We do not sell to patients.
- CAS No.: 2562386-85-8
- Formula: C22H30N8O2
- Molecular Weight:438.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC1 0.21 μM (IC50) |
HDAC6 0.021 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
88.46 μM
Compound: 12c
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Antiproliferative activity in human A549 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Antiproliferative activity in human A549 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
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[PMID: 32061484] |
| MCF7 | IC50 |
83.34 μM
Compound: 12c
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Antiproliferative activity in human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Antiproliferative activity in human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
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[PMID: 32061484] |
| MDA-MB-231 | IC50 |
21.4 μM
Compound: 12c
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Antiproliferative activity in human MDA-MB-231 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Antiproliferative activity in human MDA-MB-231 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
|
[PMID: 32061484] |
HDAC-IN-46 (compound 12c) has antiproliferative activity against MDA-MB-231, A549 and MCF-7 with IC50s of 88.46±10.5 μM, 83.34 ± 15.5 μM and 21.4±3.7 μM, respectively[1].
HDAC-IN-46 (5, 12.5 and 25 μM; 24 h) causes concentration-dependent upregulation of p-p38 and downregulation of Bcl-xL and cyclin D1 in MDA-MB-231 cells[1].
HDAC-IN-46 (12.5 and 25 μM; 48 h) induces significant G2 phase arrest and apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:5, 12.5 and 25 μM
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Incubation Time:24 h
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Result:Caused concentration-dependent upregulation of p-p38 and downregulation of Bcl-xL and cyclin D1.
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Cell Line:MDA-MB-231 cells
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Concentration:12.5 and 25 μM
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Incubation Time:48 h
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Result:Induced significant G2 phase arrest and apoptosis.
Chemical Information
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CAS No. 2562386-85-8
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Molecular Weight 438.53
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Formula C22H30N8O2
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SMILES
O=C(NO)CCCCCCCN1N=NC(C2=CC=C(C3=C(CC)N=C(N)N=C3N)C=C2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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