2562386-85-8
Chemical Structure
HDAC-IN-46
- CAS No.: 2562386-85-8
- Formula:C22H30N8O2
- Molecular Weight:438.53
IUPAC Name: 8-(4-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl)-1H-1,2,3-triazol-1-yl)-N-hydroxyoctanamide
InChIKey: CGKUMULSZZUXMU-UHFFFAOYSA-N
SMILES: O=C(NO)CCCCCCCN1N=NC(C2=CC=C(C3=C(CC)N=C(N)N=C3N)C=C2)=C1
Biological Activity: HDAC-IN-46 (compound 12c) is a potent HDAC inhibitor with an IC50 value of 0.21 μM and 0.021 μM for HDAC1 and HDAC6, respectively. HDAC-IN-46 upregulates p-p38, and downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells. HDAC-IN-46 induces significant G2 phase arrest and apoptosis. HDAC-IN-46 can be used for researching triple-negative breast cancer (TNBC)[1].
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HDAC-IN-46 | HDAC-IN-46 (compound 12c) is a potent HDAC inhibitor with an IC50 value of 0.21 μM and 0.021 μM for HDAC1 and HDAC6, respectively. HDAC-IN-46 upregulates p-p38, and downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells. HDAC-IN-46 induces significant G2 phase arrest and apoptosis. HDAC-IN-46 can be used for researching triple-negative breast cancer (TNBC). | |||||||||||||||||||||
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Keywords
