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Cat. No.: HY-160050

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CD63-1 aptamer sodium

CD63-1 aptamer sodium is a high-affinity and specific DNA aptamer targeting the CD63 protein (K_d= 38.71 nM). CD63-1 aptamer sodium effectively binds to CD63-positive cells and serves as an exosome isolation reagent. CD63-1 aptamer sodium is applicable to breast cancer-related research.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CD63-1 aptamer sodium Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

Kd: 38.71 nM (CD63)^[1]

In Vitro

CD63-1 aptamer (0-500 nM; 1 h) specifically binds to CD63-positive MDA-MB-231 and HEK293T/CD63 cells with equilibrium dissociation constants (K_d) of 96.92 nM and 113.20 nM, respectively, and does not bind significantly to CD63-negative HEK293T cells^[1].
CD63-1 aptamer (200 nM; 30 min) specifically binds to the surface of CD63-positive MDA-MB-231 and HEK293T/CD63 cells, with no detectable binding to CD63-negative HEK293T cells, as visualized by confocal microscopy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

CD63-positive MDA-MB-231 breast cancer cells, CD63-positive HEK293T/CD63 cells, CD63-negative HEK293T cells
Concentration:

200 nM
Incubation Time:

30 min
Result:

Produced strong green fluorescence signal on CD63-positive MDA-MB-231 and HEK293T/CD63 cells.
Showed no detectable signal on CD63-negative HEK293T cells.

Chemical Information

SMILES

[CD63-1 aptamer (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (1518 KB)

References

[1]. Song Z, Mao J, Barrero RA, Wang P, Zhang F, Wang T. Development of a CD63 Aptamer for Efficient Cancer Immunochemistry and Immunoaffinity-Based Exosome Isolation. Molecules. 2020 Nov 27;25(23):5585. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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