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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

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monoclonal antibody (mAb)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (4) Antibody-Drug Conjugates (ADCs) (1) ADAMTS (1) ADC Payload (3) Akt (2) Amyloid-β (1) Apoptosis (3) Biochemical Assay Reagents (3) c-Fms (2) c-Kit (1) c-Myc (1) C-type Lectin-like Receptors (CTLRs) (3) Cadherin (1) CCR (1) CD19 (1) CD47 (4) CD6 (1) CD73 (5) Complement System (2) CXCR (1) DNA/RNA Synthesis (4) Drug-Linker Conjugates for ADC (1) EGFR (4) ERK (1) Estrogen Receptor/ERR (1) Fc Receptor (FcR) (1) Ferroptosis (1) FGFR (1) Filovirus (1) GCGR (1) Glycoprotein VI (1) Histamine Receptor (1) HIV (3) IFNAR (5) IGF-1R (2) Influenza Virus (5) Integrin (2) Interleukin Related (18) Isotope-Labeled Compounds (1) JNK (1) LAG-3 (7) LILRB (3) LPL Receptor (2) MDM-2/p53 (1) MHC (1) MMP (2) Mucin (2) nAChR (1) Neurokinin Receptor (1) NF-κB (3) Notch (3) Nucleoside Antimetabolite/Analog (2) Orexin Receptor (OX Receptor) (5) p38 MAPK (2) PAI-1 (2) PCSK9 (2) PD-1/PD-L1 (17) Phosphatase (1) PSMA (2) Reactive Oxygen Species (ROS) (1) RSV (7) SARS-CoV (10) Ser/Thr Protease (1) Sialyltransferase (1) SLC39 (Zinc Transporter) (1) STAT (3) Tau Protein (4) TGF-β Receptor (3) Thyroid Hormone Receptor (1) Tie (2) Tim3 (3) Tissue Factor Pathway Inhibitor (TFPI) (1) TNF Receptor (26) Toll-like Receptor (TLR) (4) Topoisomerase (1) Transferrin Receptor (2) Transmembrane Glycoprotein (24) Transthyretin (TTR) (1) TREM receptor (1) Trk Receptor (4) TROP2 (1) VEGFR (8) VISTA (2) Wnt (3)
By Research Areas:	Cancer (137) Cardiovascular Disease (4) Endocrinology (4) Infection (28) Inflammation/Immunology (55) Metabolic Disease (9) Neurological Disease (16)
Oligonucleotides:	Guanosine (1) Nucleoside Analogs (1)

231

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

224

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: ADC Antibody Antibody-Drug Conjugates (ADCs) Antibody-Oligonucleotide Conjugates (AOCs) ADC Linker PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99113

Inebilizumab 1 Publications Verification MEDI-551	ADC Antibody CD19	Inflammation/Immunology
Inebilizumab is an anti-CD19 monoclonal antibody (mAb) with enhanced antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab can be used for multiple sclerosis and neuromyelitis optica research .

HY-P991471

GB-0895	Interleukin Related	Inflammation/Immunology
GB-0895 is a human monoclonal antibody (mAb) targeting TSLP. GB-0895 can be used in Asthma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P99589

Sotevtamab 16B5; AB-16B5	Apoptosis	Cancer
Sotevtamab (16B5) is a humanized IgG2 anti-clusterin monoclonal antibody (mAb). Sotevtamab is an inhibitor of the epithelial to mesenchymal transition. Sotevtamab can be used for cancer research .

HY-P99181

Mupadolimab CPI-006	CD73	Infection Inflammation/Immunology Cancer
Mupadolimab (CPI-006) is an IgG1κ humanized FcγR binding-deficient anti-CD73 monoclonal antibody (mAb) that activates CD73 ^POS B cells .

HY-P99941

Retifanlimab INCMGA-00012; MGA-012	PD-1/PD-L1	Cancer
Retifanlimab is an anti-programmed cell death protein 1 (anti-PD-1) monoclonal antibody (mAb). Retifanlimab can be used for the research of gastroesophageal adenocarcinoma (GEA) .

HY-P99383

Volagidemab REMD-477; AMG-477	GCGR	Metabolic Disease
Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D) .

HY-P991422

Stromab DS9231; TS-23; CSL-301	PAI-1	Cardiovascular Disease Neurological Disease
Stromab (DS9231) is a human IgG1 monoclonal antibody (mAb) targeting Serpin F2. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991451

Anti-ALPP Antibody SGN-ALPV antibody	Phosphatase	Cancer
Anti-ALPP Antibody (SGN-ALPV antibody) is a human monoclonal antibody (mAb) targeting ALPP. Anti-ALPP Antibody can be used in solid tumors research .

HY-P990302

Anti-Human/Rat/Fish AChR Antibody (Mab35)	nAChR	Neurological Disease
Anti-Human/Rat/Fish AChR Antibody (Mab35) is an anti-human/rat/fish AChR IgG1 monoclonal antibody. Anti-Human/Rat/Fish AChR Antibody (Mab35) can attack the AChR of neuromuscular junctions. Anti-Human/Rat/Fish AChR Antibody (Mab35) can be used for the construction of myasthenia gravis models .

HY-P991312

CM-338	Ser/Thr Protease	Metabolic Disease
CM-338 is a human monoclonal antibody (mAb) targeting MASP2. CM-338 can be used in IgA nephropathy research.

HY-P99409

Oregovomab Alt-2 monoclonal antibody; MAB-B43.13; Oregovamab	Transmembrane Glycoprotein	Cancer
Oregovomab (Alt-2 monoclonal antibody) is a murine mAb targeting CA125. Oregovomab induces cytotoxic immune response against CA125 expressing tumor cells .

HY-P991359

Anti-FOLH1/PSMA Antibody (J591) MEDI3726 antibody; ADCT-401 antibody	PSMA ADC Antibody	Cancer
Anti-FOLH1/PSMA Antibody (J591) (MEDI3726 antibody) is a human monoclonal antibody (mAb) targeting FOLH1/PSMA. Anti-FOLH1/PSMA Antibody (J591) can be used in Prostate cancer research .

HY-P991083

MAS825 Arumakimig	Interleukin Related	Inflammation/Immunology
MAS82590 (Arumakimig) is a bispecific IL-1β and IL-18 monoclonal antibody that reduces inflammasome-mediated inflammation. MAS825 combines the anti-IL-1β and anti-IL-18 monoclonal antibodies (mAbs) inhibition domains in a single bispecific high-affinity cytokine capture molecule .

HY-P991252

XmAb-7195 AIMab-7195	Histamine Receptor	Inflammation/Immunology
XmAb-7195 (AIMab-7195) is a human monoclonal antibody (mAb) targeting IGHE. XmAb-7195 can be used in Food hypersensitivity, Allergic asthma, Allergic rhinitis, Atopic dermatitis and Conjunctivitis research .

HY-P991396

LY-3321367	Tim3	Cancer
LY-3321367 is a human monoclonal antibody (mAb) targeting TIM-3/HAVCR2/CD366. LY-3321367 can be used in solid tumors research .

HY-P99626

Frovocimab LY 3015014	PCSK9	Metabolic Disease
Frovocimab (LY 3015014) is a humanized IgG4 monoclonal antibody (mAb) that neutralizes PCSK9. Frovocimab inhibits PCSK9 binding to LDL receptor (LDLR) while permitting the normal proteolytic cleavage of the bound intact PCSK9 .

HY-P99825

Relfovetmab	TNF Receptor	Neurological Disease Inflammation/Immunology
Relfovetmab is an anti-NGF monoclonal antibody (mAb) .

HY-P991389

BAT-6005	Transmembrane Glycoprotein	Cancer
BAT-6005 is a human monoclonal antibody (mAb) targeting TIGIT. BAT-6005 can be used in Tumor Immunity research .

HY-P9801

Anti-Spike-RBD mAb 1 Publications Verification SARS-CoV-2 (2019-nCoV) Spike RBD antibody	SARS-CoV	Infection
Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of Spike protein and ACE2. Anti-Spike-RBD mAb is a potential therapeutic approach for SARS-CoV-2 treatment .

HY-P99820

Ranevetmab NV-01	TNF Receptor	Inflammation/Immunology
Ranevetmab (NV-01) is a caninised anti-NGF monoclonal antibody (mAb). Ranevetmab can alleviate pain, and is used for the research of degenerative joint disease (DJD) pain .

HY-P991326

BL-9020 EDP-10; JHL-1311	Interleukin Related	Endocrinology
BL-9020 is a human monoclonal antibody (mAb) targeting NKp46/NCR1. BL-9020 can be used in type 1 diabetes mellitus research.

HY-P991439

BIIB023	TNF Receptor	Inflammation/Immunology
BIIB023 is a human monoclonal antibody (mAb) targeting TNFRSF12A/TWEAKR/CD266. BIIB023 can be used in lupus nephritis and rheumatoid arthritis research .

HY-P991341

FF-21101	Cadherin	Inflammation/Immunology
FF-21101 is a human IgG1 monoclonal antibody (mAb) targeting CDH3/P-cadherin. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991360

MLN 591 MLN2704 antibody	PSMA	Cancer
MLN 591 is a human monoclonal antibody (mAb) targeting PSMA. MLN 591 can be used in Prostate cancer research .

HY-P991383

LY2382770	TGF-β Receptor	Metabolic Disease
LY2382770 is a human monoclonal antibody (mAb) targeting TGFB1. LY2382770 can be used in dabetic nephropathies research .

HY-P991476

MDX-220	Fc Receptor (FcR)	Cancer
MDX-220 is a human monoclonal antibody (mAb) targeting FcRn. MDX-220 has anti-tumor activity .

HY-P991470

Anti-Tenascin C Antibody Neuradiab antibody	Transmembrane Glycoprotein	Cancer
Anti-Tenascin C Antibody (Neuradiab antibody) is a human monoclonal antibody (mAb) targeting Tenascin C. Anti-Tenascin C Antibody can be used in Glioblastoma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991293

NN-2101	c-Kit	Metabolic Disease
NN-2101 is a human monoclonal antibody (mAb) targeting c-Kit/CD117. NN-2101 is used in the research of retinal disorders and diabetic macular edema.

HY-P991306

ATG-032	LILRB Transmembrane Glycoprotein	Cancer
ATG-032 is a human monoclonal antibody (mAb) targeting LILRB2/ILT4. ATG-032 can be used in haematological malignancies research.

HY-P991497

ASN-500	RSV	Infection
ASN-500 is a human monoclonal antibody (mAb) targeting F/Fusion glycoprotein F0. ASN-500 can be used in respiratory syncytial virus infection research .

HY-P991500

EVO-46135	RSV	Infection
EVO-46135 is a human monoclonal antibody (mAb) targeting F/Fusion glycoprotein F0. EVO-46135 can be used in Respiratory syncytial virus infections and Metapneumovirus infections research.

HY-P991434

SAN-300	Integrin	Inflammation/Immunology
SAN-300 is a human IgG1 monoclonal antibody (mAb) targeting ITGA1/VLA-1. SAN-300 can be used in Rheumatoid arthritis research .

HY-P991436

DF6002 BMS-986415	Interleukin Related IFNAR	Cancer
DF6002 (BMS-986415) is a human monoclonal antibody (mAb) targeting IL-12. DF6002 increases IFN-γ levels. DF6002 can be used in solid tumors research .

HY-P9806

Anti-MERS-D12 mAb MERS-D12; MERS antibody-D12	SARS-CoV	Infection
Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) is a human monoclonal IgG1. Anti-MERS-D12 mAb binds directly to the DPP4 interacting region of the MERS-CoV Spike receptor binding domain (RBD) and effect neutralization by directly blocking receptor binding .

HY-P99808

Pulocimab AK-109	VEGFR	Cancer
Pulocimab is an anti-VEGFR2 monoclonal antibody (mAb). Pulocimab can be used for the research of cancers .

HY-P991379

MG1113A	Tissue Factor Pathway Inhibitor (TFPI)	Others
MG1113A is a human monoclonal antibody (mAb) targeting TFPI. MG1113A can be used in Haemophilia research.

HY-P991299

ENUM006	LAG-3	Cancer
ENUM006 is a human monoclonal antibody (mAb) targeting CD223/LAG3 .

HY-P991298

DNV-3	LAG-3	Cancer
DNV-3 is a human monoclonal antibody (mAb) targeting CD223/LAG3 .

HY-P991343

ALD306 ALD309	PCSK9	Endocrinology
ALD306 is a human monoclonal antibody (mAb) targeting PCSK9. ALD306 can be used in Hypercholesterolaemia research .

HY-P991386

PM-1021	Transmembrane Glycoprotein	Cancer
PM-1021 is a human monoclonal antibody (mAb) targeting TIGIT. PM-1021 can be used in cancer research .

HY-P991325

CRB-0089	Trk Receptor	Inflammation/Immunology
CRB-0089 is a human monoclonal antibody (mAb) targeting NGF/bNGF. CRB-0089 can be used in analgesia research.

HY-P991295

ABC-015	C-type Lectin-like Receptors (CTLRs)	Cancer
ABC-015 is a human monoclonal antibody (mAb) targeting KLRG1. ABC-015 can be used in multiple myeloma research.

HY-P991390

BAT-6021	Transmembrane Glycoprotein	Cancer
BAT-6021 is a human monoclonal antibody (mAb) targeting TIGIT. BAT-6021 can be used in Solid tumours research .

HY-P991429

THR-317	VEGFR	Metabolic Disease
THR-317 is a human monoclonal antibody (mAb) targeting PLGF. THR-317 can be used in Diabetic retinopathy research .

HY-163010

Dicamba-propionic acid	Biochemical Assay Reagents	Others
Dicamba-propionic acid (DCa3) is a heterologous hapten that can be used to develop high-affinity monoclonal antibodies (mAb) against Dicamba. The Dicamba-propionic acid- developed mAb can be used to determine the residual amount of Dicamba in environmental water samples .

HY-P991405

EU-102	TNF Receptor	Cancer
EU-102 is a human monoclonal antibody (mAb) targeting TNFSF18. EU-102 can be used in solid tumors research .

HY-P991339

ZL-1101	Orexin Receptor (OX Receptor)	Cancer
ZL-1101 is a human monoclonal antibody (mAb) targeting TNFRSF4/OX40/CD134.

HY-P991418

MW02	VEGFR	Others
MW02 is a human monoclonal antibody (mAb) targeting VEGFA. MW02 can be used in Wet age-related macular degeneration research .

HY-P991361

ABX-10241 ABX-PTH	Thyroid Hormone Receptor	Endocrinology
ABX-10241 (ABX-PTH) is a human monoclonal antibody (mAb) targeting Parathyrin. ABX-10241 can be used in Hyperparathyroidism research .

HY-P991328

MAb604.107	Notch	Cancer
MAb604.107 is a human monoclonal antibody (mAb) targeting NOTCH1. MAb604.107 inhibits the proliferation and CD34/CD44 expression of primary T-ALL cells. MAb604.107 has anti-tumor activity in four tumor xenograft mouse models: MDA-MB-231, HCC-1806, BT-474, and HCT-116. MAb604.107 can be used in T acute lymphoblastic leukemia research .

Cat. No.	Product Name

HY-L031

Small Molecule Immuno-Oncology Compound Library

788 compounds

Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines.

MCE Small Molecule Immuno-Oncology Compound Library offers 788 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.

Cat. No.	Product Name	Type

HY-D1056A3

Lipopolysaccharides, from E. coli O26:B6

LPS, from Escherichia coli (O26:B6)

Biochemical Assay Reagents

Lipopolysaccharides, from E. coli (Escherichia coli) O26:B6 are lipopolysaccharide endotoxins and TLR-4 activators derived from E. coli, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from E. coli O26:B6 exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A, and can be recognized by the core-specific monoclonal antibody MAb J8-4C10. Lipopolysaccharides, from E. coli O26:B6 can promote an increase in pro-inflammatory cytokines in plasma, thereby triggering hypothalamic-pituitary-adrenal (HPA) activation and leading to adrenal oxidative damage. The pathogenic effects of Lipopolysaccharides, from E. coli O26:B6 can be used to construct various models, such as cellular inflammation models, sepsis, acute lung injury models, adrenal dysfunction models, and bladder infection models, etc .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

Cat. No.	Product Name	Target	Research Area

HY-P4025

ELDKWA	HIV	Others
ELDKWA is the highly conserved amino acids on the ecto-domain of gp41. ELDKWA acts as the epitope of a neutralizing monoclonal antibody 2F5 (mAb 2F5) directed against human immunodeficiency virus type 1 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-131081

γ-Amanitin	Structural Classification Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification Cancer	DNA/RNA Synthesis ADC Payload
γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC₅₀ of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells .

Cat. No.	Product Name	Chemical Structure

HY-W767399

8-Bromo-2'-deoxyguanosine-13C,15N2

8-Bromo-2'-deoxyguanosine- ¹³C, ¹⁵N2 is the ¹³C- and ¹⁵N-labeled 8-Bromo-2'-deoxyguanosine (HY-W011168). 8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H₂O₂-Cl ^--Br ^- system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation .

Cat. No.	Product Name		Classification

HY-W011168

8-Bromo-2'-deoxyguanosine		Nucleoside Analogs Guanosine
8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H₂O₂-Cl ^--Br ^- system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation .

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monoclonal antibody (mAb)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products