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Art. -Nr.: HY-P991252

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XmAb-7195

Name: XmAb-7195
Brand: MedChemExpress
SKU: HY-P991252
Price: 400.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: AIMab-7195)

Kundenbewertung

Based on 1 Customer Validation

XmAb-7195 (AIMab-7195) is an anti-IgE monoclonal antibody and FcγRIIb-targeting inhibitor. XmAb-7195 binds free IgE, preventing its binding to mast cells, reduces total IgE and free IgE levels, and promotes clearance of anti-IgE/IgE immune complexes by enhancing binding to the inhibitory Fc receptor FcγRIIb, while inhibiting the differentiation of IgE-bearing B cells. XmAb-7195 can be used for research on allergic asthma and other IgE-mediated diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.98%
Molecular Weight:146.53 kDa

Speicherung:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

XmAb-7195 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

^[1]

FcγRIIB

FCGR2B

In Vitro

XmAb-7195 (AIMab-7195) blocks the binding of IgE to mast cells, inhibits the differentiation of IgE-positive B cells, and rapidly clears total IgE and free IgE from the circulation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

/ [NCBI]

Accession

P01854

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Anwendung

ELISA, FACS, Functional assay

Chemical Information

Appearance Liquid
Molecular Weight 146.53 kDa
Color Colorless to light yellow
SMILES

N/A
Synonyms

AIMab-7195
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Gershman A, et al. D21 ASTHMA TREATMENT: GLUCOCORTICOIDS, BIOLOGICALS AND BEYOND: A Randomized, Double-Blinded, Placebo-Controlled, Ascending Dose Study Of The Safety, Tolerability, And Pharmacokinetics Of Xmab® 7195. American Journal of Respiratory and Critical Care Medicine. 2016;193:1.

[2]. Liour SS, et al. Treating IgE-mediated diseases via targeting IgE-expressing B cells using an anti-CεmX antibody. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2016 Aug;27(5):446-51. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

XmAb-7195