Anti-Human/Rat/Fish AChR Antibody (Mab35)
Based on 1 Customer Validation
Anti-Human/Rat/Fish AChR Antibody (Mab35) is an anti-human/rat/fish AChR IgG1 monoclonal antibody. Anti-Human/Rat/Fish AChR Antibody (Mab35) can attack the AChR of neuromuscular junctions. Anti-Human/Rat/Fish AChR Antibody (Mab35) can be used for the construction of myasthenia gravis models.
For research use only. We do not sell to patients.
- Purity : 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG1
Recommend Isotype Controls
Species Reactivity
Human/Rat/Fish
IC50 & Target
AChR
In Vitro
Anti-Human/Rat/Fish AChR Antibody (Mab35) (10 nM, 24 h) significantly inhibits the secretion of catecholamines in bovine adrenal chromaffin cells[2].
Anti-Human/Rat/Fish AChR Antibody (Mab35) specifically binds to the α1, α3, and α5 subunits of nAChR in TIB-175 hybridoma cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Lewis rats[1]
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Dosage:1 mg/kg
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Administration:Intravenous injection (i.v.), on the seventh day after injection of C5 siRNA/LNP
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Result:Caused weight loss in rats.
Reduced fore limb grip strength, hindlimb weakness, and partial paralysis on days 8 and 9.
Gene ID
Accession
P30532 / NP_000736.2
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
EAMG induction in rats; Immunofluorescence
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Human/Rat/Fish AChR Antibody (Mab35)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Kuboi Y, et al. Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis. Mol Ther Nucleic Acids. 2023 Jan 13;31:339-351. [Content Brief]
[2]. Gu H, et al. Characterization and localization of adrenal nicotinic acetylcholine receptors: evidence that mAb35-nicotinic receptors are the principal receptors mediating adrenal catecholamine secretion. J Neurochem. 1996 Apr;66(4):1454-61. [Content Brief]
[3]. Jin L, et al. Nicotinic receptor alpha subunits in magnocellular neurons of rat hypothalamus. Neuroreport. 2004 Oct 25;15(15):2333-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Human/Rat/Fish AChR Antibody (Mab35) Related Classifications
HY-P990302 Related Classifications
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