ADI-15878
Based on 1 Customer Validation
ADI-15878 (ADI-15742; MBP-134 AF) is an Ebola virus GP-binding antibody. ADI-15878 blocks GP-mediated membrane fusion and viral entry by binding to a conserved, non-overlapping epitope comprising the GP1 N-terminal pocket and the GP2 fusion loop. As a component of MBP134, ADI-15878 targets an epitope conserved in BDBV sequences, supporting cross-species activity against EBOV and BDBV, and can be used in combination with ADI-15946 and/or CA45 for next-generation monoclonal antibody cocktail therapy. ADI-15878 can be used for research on Bundibugyo virus disease and Ebola virus disease.
For research use only. We do not sell to patients.
- Purity : 99.80%
- Molecular Weight:144.82 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Virus
IC50 & Target
Envelope glycoprotein, GP2
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | IC50 |
0.48 μg/mL
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Neutralization of EBOV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
Neutralization of EBOV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
|
41878634 |
| Huh-7 | IC50 |
0.01 μg/mL
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Neutralization of BDBV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
Neutralization of BDBV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
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41878634 |
| Huh-7 | IC50 |
0.04 μg/mL
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Neutralization of SUDV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
Neutralization of SUDV GP-pseudotyped particles in human Huh7 cells assessed by luciferase activity 48 hrs post-transduction.
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41878634 |
| Huh-7 | IC50 |
0.29 μg/mL
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Neutralization of EBOV GP-pseudotyped particles in human Huh7 cells in Frame-2 background assessed by luciferase activity 48 hrs post-transduction.
Neutralization of EBOV GP-pseudotyped particles in human Huh7 cells in Frame-2 background assessed by luciferase activity 48 hrs post-transduction.
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41878634 |
In Vitro
ADI-15878 (50-0.016 µg/mL; 1 h at room temperature) binds to 293T cells expressing wild-type EBOV-GP, and at 10 ng/mL its binding to the G528E mutant decreases sharply, with only 1% of cells in the Q3 region[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Molecular Weight 144.82 kDa
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Color Colorless to light yellow
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SMILES
[ADI-15878]
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Synonyms
ADI-15742; MBP-134 AF
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ADI-15878 Related Classifications
HY-P991450 Related Classifications
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