GP2 - glycoprotein 2 Gene

Homo sapiens

Also known as ZAP75

Gene ID: 2813 | Gene type: protein coding

About GP2

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,309,574-20,327,513 (from NCBI)

This gene has 11 transcripts (splice variants), 374 orthologues and 5 paralogues. Restricted expression toward pancreas (RPKM 2558.6).

Summary

This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GP2 Products(4)

mRNA	Protein	Name
NM_001007240.3	NP_001007241.2	pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein
NM_001007241.3	NP_001007242.2	pancreatic secretory granule membrane major glycoprotein GP2 isoform 3 precursor
NM_001007242.3	NP_001007243.2	pancreatic secretory granule membrane major glycoprotein GP2 isoform 4 precursor
NM_001502.4	NP_001493.2	pancreatic secretory granule membrane major glycoprotein GP2 isoform 2 precursor

GP2 Protein Structure

Zona_pellucida

0
100
200
300
400
500
537 a.a.

Protein Preferred Names

Protein Names

pancreatic secretory granule membrane major glycoprotein GP2

glycoprotein 2 (zymogen granule membrane)

Related Diseases

Diseases

Alias

Argentine Hemorrhagic Fever

Argentinian Hemorrhagic Fever	Junin Hemorrhagic Fever
Hemorrhagic Fever, Argentinian	Ahf - [Argentinian Haemorrhagic Fever]
Argentine Haemorrhagic Fever	Junin Haemorrhagic Fever

Bolivian Hemorrhagic Fever

Machupo Hemorrhagic Fever	Hemorrhagic Fever, Bolivian
Bhf - [Bolivian Haemorrhagic Fever]	Machupo Haemorrhagic Fever

Venezuelan Hemorrhagic Fever

Guanarito Hemorrhagic Fever

Vehf - [Venezuelan Haemorrhagic Fever]

Marburg Hemorrhagic Fever

Marburg Virus Disease	Marburg Disease
Green Monkey Disease	Mhf
Vervet Monkey Disease	Mard - [Marburg Disease]
Mvd - [Marburg Virus Disease]	Marburg Haemorrhagic Fever
Mhf - [Marburg Haemorrhagic Fever]

Inflammatory Bowel Disease 29

IBD29

{Inflammatory Bowel Disease 29}

Brazilian Hemorrhagic Fever

Sabia Hemorrhagic Fever

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Lassa Fever

Lf	Lassa Hemorrhagic Fever
Lf - [Lassa Fever]

Lujo Hemorrhagic Fever

Zambian Hemorrhagic Fever

Foodborne Botulism

Botulism	Botulism Poisoning
Intoxication With Clostridium Botulinum Toxin	Wound Botulism
Food Poisoning Due To Clostridium Botulinum	Infection Due To Clostridium Botulinum
Infant Botulism	Intoxication Botulism
Botulism, Infantile	Clostridium Botulinum Poisoning
Botulism Nos

Acute Pancreatitis

Pancreatitis	Pancreatitis, Acute Necrotizing
Pancreatitis Nos	Acute Pancreas Inflammation

Blessig'S Cysts

Microcystoid Retinal Degeneration	Blessig Cysts
Iwanoff'S Cysts	Microcystoid Degeneration Of Retina

De Quervain Disease

Radial Styloid Tenosynovitis	Tenosynovitis, De Quervain'S
De Quervain'S Disease	Tenosynovitis Of Radial Styloid Process
Stenosans Tenosynovitis

Intestinal Tuberculosis

Tuberculosis Of Intestine

Tuberculosis Of Intestines

Bagassosis

Sugar Cane Worker Pneumonitis	Bagasse Workers' Lung
Bagasse Disease	Bagasse Disease Or Pneumonitis
Bagasse Workers' Disease	Fibrosis Of Lung With Bagassosis
Sugar Cane Workers' Hypersensitivity Pneumonitis	Bagasse Pneumonitis
Hypersensitivity Pneumonitis With Bagassosis

Gastrointestinal Tuberculosis

Tuberculosis Of Intestines, Peritoneum And Mesenteric Glands	Tuberculosis, Gastrointestinal
Tuberculosis Of Gastrointestinal Tract	Tuberculosis Of Intestines, Peritoneum, And Mesenteric Glands

Stuttering

Stammering	Familial Persistent Stuttering
Stuttering, Familial Persistent 1

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17367A	Atazanavir sulfate		99.94%	Yes
HY-17367	Atazanavir		99.23%	Yes

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147089	PRRSV/CD163-IN-1	Inhibitor	98.55%	Unkown
HY-P1855	HER2/neu (654-662) GP2		98.04%	Unkown
HY-107471	CB2 receptor agonist 3	Agonist	99.86%	Unkown
HY-17367S2	Atazanavir-d9		/	Unkown
HY-17367S3	Atazanavir-d5		/	Unkown
HY-17367S4	Atazanavir-d6		99.28%	Unkown
HY-P5695	GP-2B	Inhibitor	/	Unkown
HY-RS05609	GP2 Human Pre-designed siRNA Set A		/	Unkown
HY-U00191	GP2-114		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GP2	RGD	RGD:621695
Macaca mulatta	GP2	VGNC	VGNC:73114
Mus musculus	GP2	MGD	MGI:1914383
Bos taurus	GP2	VGNC	VGNC:29505
Canis familiaris	GP2	VGNC	VGNC:41356
Felis catus	GP2	VGNC	VGNC:80577
Macaca fascicularis	GP2	NCBI
Others	GP2	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.