country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187472

Copy Link Print Information

SMA-245

SMA-245 is an inhibitor of Filovirus glycoproteins, acting on Ebola virus (EBOV) and Marburg virus (MARV). SMA-245 blocks the endosomal membrane fusion step of filoviruses by binding to the EBOV GP1/GP2 fusion loop. SMA-245 inhibits MARV viral entry. SMA-245 can be used in research related to filovirus infections.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₉H₃₂N₂O₂
Masse moléculaire:440.58

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SMA-245 Chemical Structure

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

EBOV

MARV

Voir tous les produits spécifiques à Isoform Filovirus :

Voir tous les produits spécifiques à Isoform Cytochrome P450 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	6.8 μM	Cytotoxicity against human A549 lung epithelial cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation. Cytotoxicity against human A549 lung epithelial cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation.	42475249
HeLa	CC₅₀	4.6 μM	Cytotoxicity against human HeLa cervical cancer cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation. Cytotoxicity against human HeLa cervical cancer cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation.	42475249

In Vitro

SMA-245 (compound 41) (48 h) potently inhibits pEBOV entry in A549 cells with an EC₅₀ of 0.040 μM, also inhibits pMARV, pSUDV, and pTAFV entry, shows no activity against pBDBV, and has low activity against non-filovirus pseudoviruses^[1].
SMA-245 (40 h infection incubation; 48 h cytotoxicity incubation) potently inhibits infectious EBOV replication in HeLa cells with an EC₅₀ of 0.04 μM and infectious MARV replication with an EC₅₀ of 0.38 μM, with selectivity indices of 120 and 12, respectively^[1].
SMA-245 moderately inhibits hERG potassium channels with an IC₅₀ of 2.93 μM, representing a potential cardiac safety concern^[1].
SMA-245 has excellent plasma stability in human and mouse, high stability in human liver microsomes, moderate stability in mouse liver microsomes, and low to moderate inhibition of major CYP450 isoforms at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_last	AUC_0-∞	T_1/2	MRT_0-∞	C₀	CL	V_ss	T_max	C_max	C_min	Bioavailability
Mice^[1]	5 mg/kg	i.v.	2416 ng·h/mL	2585 ng·h/mL	6.8 h	7.1 h	1224 ng/mL	32 mL/min/kg	14 L/kg	/	/	/	/
Mice^[1]	50 mg/kg	p.o.	1637 ng·h/mL	1672 ng·h/mL	4.1 h	5.8 h	/	/	/	4.0 h	210 ng/mL	5.8 ng/mL	6.47 %

In Vivo

SMA-245 (compound 41) (5-50 mg/kg; i.v., p.o.; single bolus) exhibits favorable in vivo pharmacokinetic properties following i.v. administration in male BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 440.58
Formule C₂₉H₃₂N₂O₂
SMILES

COC1=CC2=C(C(C(CC2)C3=CC=CC=C3)C4=CC=C(C=C4)NC(C5CCNCC5)=O)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Aboukhatwa SM, et al. Configurationally Locked Ridaifen-B Analogs as Potent Ebola Virus Entry Inhibitors. Journal of medicinal chemistry. 2026 Jul 20.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

SMA-245

Voir tous les produits spécifiques à Isoform Filovirus

Voir tous les produits spécifiques à Isoform Cytochrome P450