2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. CB2 receptor agonist 3

CB2 receptor agonist 3  (Synonyms: GP2a)

Cat. No.: HY-107471 Purity: 99.86%
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CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with Kis of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells.

For research use only. We do not sell to patients.

CB2 receptor agonist 3 Chemical Structure

CB2 receptor agonist 3 Chemical Structure

CAS No. : 919077-81-9

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Based on 1 publication(s) in Google Scholar

CB2 receptor agonist 3 Related Antibodies

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Description

CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with Kis of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells[1].

In Vitro

CB2 receptor agonist 3 (Compound 2a) is also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB2 receptor agonist 3 Related Antibodies
Molecular Weight

440.36

Formula

C24H23Cl2N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN(C2=C1CC3=C2C=CC(C)=C3)C4=CC=C(C=C4Cl)Cl)NC5CCCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (28.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2709 mL 11.3543 mL 22.7087 mL
5 mM 0.4542 mL 2.2709 mL 4.5417 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2709 mL 11.3543 mL 22.7087 mL 56.7717 mL
5 mM 0.4542 mL 2.2709 mL 4.5417 mL 11.3543 mL
10 mM 0.2271 mL 1.1354 mL 2.2709 mL 5.6772 mL
15 mM 0.1514 mL 0.7570 mL 1.5139 mL 3.7848 mL
20 mM 0.1135 mL 0.5677 mL 1.1354 mL 2.8386 mL
25 mM 0.0908 mL 0.4542 mL 0.9083 mL 2.2709 mL
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CB2 receptor agonist 3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB2 receptor agonist 3919077-81-9GP2aCannabinoid ReceptorpromyelocyticleukemiaHL-60cellsligandInhibitorinhibitorinhibit

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