2. Immunology/Inflammation
  3. Interleukin Related IFNAR
  4. DF6002

DF6002 (BMS-986415) is a monovalent IL-12 immunoglobulin Fc fusion protein. DF6002 can promote sustained IFN-γ responses while reducing toxicity. DF6002 binds specifically to IL-12R on CD4+ T cells, CD8+ T cells, NK cells, and B cells. DF6002 can be used for the research of solid tumors .

For research use only. We do not sell to patients.

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DF6002 Related Antibodies

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Description

DF6002 (BMS-986415) is a monovalent IL-12 immunoglobulin Fc fusion protein. DF6002 can promote sustained IFN-γ responses while reducing toxicity. DF6002 binds specifically to IL-12R on CD4+ T cells, CD8+ T cells, NK cells, and B cells. DF6002 can be used for the research of solid tumors [1].

IC50 & Target[1]

IL-2

 

In Vitro

DF6002 (200 nM) specifically binds to IL-12 receptor-expressing CD4+ T cells, CD8+ T cells, NK cells, and weakly to B cells in activated human PBMCs[1].
DF6002 (0.00596-6250 pM; 72 h) induces IFN-γ production in activated human PBMCs with an EC50 of 2.99 pM[1].
DF6002 (200 nM) specifically binds to IL-12 receptor-expressing CD4+ T cells, CD8+ T cells, NK cells, and weakly to B cells in activated cynomolgus monkey PBMCs[1].
DF6002 (0.00596-6250 pM; 72 h) induces IFN-γ production in activated cynomolgus monkey PBMCs with an EC50 of 6.91 pM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DF6002 Related Antibodies
Parmacokinetics
Species Dose Route T1/2
Cynomolgus Monkey[1] 1 mg/kg i.v. 17.4-30.5 h
In Vivo

DF6002 (1-19 µg/kg; i.v.) exhibits prolonged in vivo half-life in cynomolgus monkeys, induces a sustained, potent IFNγ response at 1 µg/kg, and is well tolerated at doses up to 19 µg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys[1]
Dosage: 1 µg/kg (IFNγ response); 19 µg/kg (tolerance, IFNγ response)
Administration: i.v.; bolus on Days 1 and 8 (1 µg/kg); single dose (19 µg/kg)
Result: Demonstrated in vivo half-life ranging from 17.4-30.5 h.
Induced peak IFNγ levels at 48 h post-dose (141-226 pg/mL) at 1 µg/kg.
Was well tolerated without cytokine release syndrome, fever, or adverse toxicity at 19 µg/kg.
Caused minor, dose-dependent minimal increases in aspartate aminotransferase and alanine aminotransferase activities in the liver.
Caused minor, dose-dependent mild decreases in white blood cells and altered cellularity in secondary lymphoid tissue.
Clinical Trial
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[DF6002]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • human version of IL-12-Fc
Purity & Documentation
References
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DF6002 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DF6002BMS-986415DF 6002DF-6002BMS986415BMS 986415Interleukin RelatedIFNARILInterferon-α/β receptorInterferon-alpha/beta receptorinterferon-gammacynomolgus monkeysB cellsperipheral blood mononuclear cellssolid tumorsinterleukin-12 receptorNK cellsIL-12RCD4+ T cellsCD8+ T cellsInhibitorinhibitorinhibit

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