Anti-Mouse CD80/B7-1 Antibody (RM80)

製品番号: HY-P990127 純度: 95%: Data Sheet SDS COA
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Anti-Mouse CD80/B7-1 Antibody (RM80) is an anti-mouse CD80/B7-1 IgG2a monoclonal antibody. Anti-Mouse CD80/B7-1 Antibody (RM80) can inhibit the number of tissue-resident memory (T_RM) cells. Anti-Mouse CD80/B7-1 Antibody (RM80) can prolong the survival time of transplants combined with CD86 mAb. Anti-Mouse CD80/B7-1 Antibody (RM80) can be used for researches on inflammation conditions and immunology such as viral myocarditis and corneal transplant.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Anti-Mouse CD80/B7-1 Antibody (RM80) 構造式

容量	価格（税別）	在庫状況	数量
1 mg	$220	在庫あり	Estimated Time of Arrival: December 31
5 mg	$650	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1050	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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製品説明

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

CD80/B7-1

体内実験

Anti-Mouse CD80/B7-1 Antibody (RM80) (5 mg/kg, i.p., on day 0 and day 3) significantly alleviates myocarditis in male C3H/He mice with a viral myocarditis model^[1].
Anti-Mouse CD80/B7-1 Antibody (RM80) (300 μg, i.p., twice weekly, for 2 weeks) significantly inhibits the proliferation of E7 specific CD8⁺ T cells and the formation of tissue-resident memory (T_RM) cells in C57BL/6 mice injected with Ad-R9F vaccine^[2].
Anti-Mouse CD80/B7-1 Antibody (RM80) (0.1 and 0.25 mg, i.p., on day 0, 2, 4, 6, and 8 after transplantation) significantly prolongs corneal graft survival combined with CD86 mAb in male BALB/c (H-2^d) mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	1×10⁹ pfu CVB3 virus injected male C3H/He mice (5 weeks)^[1]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.), on day 0 and day 3
Result:	Significantly reduced the area of myocarditis to 6.00 %.

Animal Model:	1×10⁹ IU Ad-R9F vaccine injected C57BL/6 mice (6-8 weeks)^[2]
Dosage:	300 μg, combined with CD86 mAb (300 μg)
Administration:	Intraperitoneal injection (i.p.), twice weekly, for 2 weeks
Result:	Significantly reduced the number of E7 specific CD8⁺ T cells in the early stages. Had a relatively small impact in the later stage.

Animal Model:	Male BALB/c (H-2^d) mice (6-8 weeks)^[3]
Dosage:	0.1 and 0.25 mg
Administration:	Intraperitoneal injection (i.p.), on day 0, 2, 4, 6, and 8 after transplantation
Result:	Significantly prolonged the survival time of transplants. Significantly reduced edema and infiltration. Significantly reduced CD80⁺ cells.

Gene ID

12519 [NCBI]

Accession

Q00609

Application

in vivo CD80 blockade; in vitro CD80 blockade; Flow cytometry

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD80/B7-1 Antibody (RM80)]

Formulation

Please refer to the lot-specific COA for specific buffer information.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

純度: 95%

Select Batch:

データシート (262 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Seko Y, et al. Expression of costimulatory molecule CD40 in murine heart with acute myocarditis and reduction of inflammation by treatment with anti-CD40L/B7-1 monoclonal antibodies. Circ Res. 1998 Aug 24;83(4):463-9. [Content Brief]

[2]. van der Gracht ET, et al. Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer. J Immunother Cancer. 2020 Dec;8(2):e001133. [Content Brief]

[3]. Kagaya F, et al. Inhibition of murine corneal allograft rejection by treatment with antibodies to CD80 and CD86. Exp Eye Res. 2002 Jan;74(1):131-9. [Content Brief]

Anti-Mouse CD80/B7-1 Antibody (RM80) Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD80/B7-1 Antibody (RM80)Transmembrane GlycoproteinCD80/B7-1T cellsmyocarditisCVB3corneal transplantInhibitorinhibitorinhibit

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