Anti-Mouse CD80/B7-1 Antibody (RM80)

Cat. No.: HY-P990127 Purity: 95%: Data Sheet
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Anti-Mouse CD80/B7-1 Antibody (RM80) is an anti-mouse CD80/B7-1 IgG2a monoclonal antibody. Anti-Mouse CD80/B7-1 Antibody (RM80) can inhibit the number of tissue-resident memory (T_RM) cells. Anti-Mouse CD80/B7-1 Antibody (RM80) can prolong the survival time of transplants combined with CD86 mAb. Anti-Mouse CD80/B7-1 Antibody (RM80) can be used for researches on inflammation conditions and immunology such as viral myocarditis and corneal transplant.

For research use only. We do not sell to patients.

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

CD80/B7-1

In Vivo

Anti-Mouse CD80/B7-1 Antibody (RM80) (5 mg/kg, i.p., on day 0 and day 3) significantly alleviates myocarditis in male C3H/He mice with a viral myocarditis model^[1].
Anti-Mouse CD80/B7-1 Antibody (RM80) (300 μg, i.p., twice weekly, for 2 weeks) significantly inhibits the proliferation of E7 specific CD8⁺ T cells and the formation of tissue-resident memory (T_RM) cells in C57BL/6 mice injected with Ad-R9F vaccine^[2].
Anti-Mouse CD80/B7-1 Antibody (RM80) (0.1 and 0.25 mg, i.p., on day 0, 2, 4, 6, and 8 after transplantation) significantly prolongs corneal graft survival combined with CD86 mAb in male BALB/c (H-2^d) mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	1×10⁹ pfu CVB3 virus injected male C3H/He mice (5 weeks)^[1]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.), on day 0 and day 3
Result:	Significantly reduced the area of myocarditis to 6.00 %.

Animal Model:	1×10⁹ IU Ad-R9F vaccine injected C57BL/6 mice (6-8 weeks)^[2]
Dosage:	300 μg, combined with CD86 mAb (300 μg)
Administration:	Intraperitoneal injection (i.p.), twice weekly, for 2 weeks
Result:	Significantly reduced the number of E7 specific CD8⁺ T cells in the early stages. Had a relatively small impact in the later stage.

Animal Model:	Male BALB/c (H-2^d) mice (6-8 weeks)^[3]
Dosage:	0.1 and 0.25 mg
Administration:	Intraperitoneal injection (i.p.), on day 0, 2, 4, 6, and 8 after transplantation
Result:	Significantly prolonged the survival time of transplants. Significantly reduced edema and infiltration. Significantly reduced CD80⁺ cells.

Gene ID

12519 [NCBI]

Accession

Q00609

Application

in vivo CD80 blockade; in vitro CD80 blockade; Flow cytometry

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD80/B7-1 Antibody (RM80)]

Formulation

Please refer to the lot-specific COA for specific buffer information.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

产品图

Purity & Documentation

Purity: 95%

Select Batch:

Data Sheet (262 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Seko Y, et al. Expression of costimulatory molecule CD40 in murine heart with acute myocarditis and reduction of inflammation by treatment with anti-CD40L/B7-1 monoclonal antibodies. Circ Res. 1998 Aug 24;83(4):463-9. [Content Brief]

[2]. van der Gracht ET, et al. Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer. J Immunother Cancer. 2020 Dec;8(2):e001133. [Content Brief]

[3]. Kagaya F, et al. Inhibition of murine corneal allograft rejection by treatment with antibodies to CD80 and CD86. Exp Eye Res. 2002 Jan;74(1):131-9. [Content Brief]

Anti-Mouse CD80/B7-1 Antibody (RM80) Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD80/B7-1 Antibody (RM80)Transmembrane GlycoproteinCD80/B7-1T cellsmyocarditisCVB3corneal transplantInhibitorinhibitorinhibit

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