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Toralizumab

(Synonyms: IDEC-131; Anti-Human CD40 ligand Recombinant Antibody)
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Based on 1 Customer Validation

Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab is an immunosuppressive agent. Toralizumab can lead to increased thrombosis. Toralizumab can be studied in research for diseases such as multiple sclerosis, systemic lupus erythematosus (SLE), and Crohn’s disease.

For research use only. We do not sell to patients.

  • Purity: 99.57%
  • CAS No.: 252662-47-8
  • Molecular Weight:145.66 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Toralizumab
  • Experimental Validation Results for Toralizumab
  • Experimental Validation Results for Toralizumab
  • Toralizumab Chemical Structure
    Toralizumab Chemical Structure
CAS No.: 252662-47-8
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Toralizumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized CD40L/CD154/TRAP Protein, Human (His, HY-P72907) can bind Toralizumab. The EC50 for this effect is 5.068 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 500 ng/mL anti-CD3 stimulated Jurkat cells (24h) labeling Toralizumab (HY-P99325, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Toralizumab Chemical Structure
    1/16
  • Toralizumab
  • Immobilized CD40L/CD154/TRAP Protein, Human (His, HY-P72907) can bind Toralizumab. The EC50 for this effect is 5.068 ng/mL.
  • Flow cytometric analysis of 1X106 500 ng/mL anti-CD3 stimulated Jurkat cells (24h) labeling Toralizumab (HY-P99325, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).