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Frexalimab

(Synonyms: SAR441344; INX-021)
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Based on 1 Customer Validation

Frexalimab (SAR441344) is a second-generation monoclonal antibody targeting the CD40 ligand (CD40L) with a good safety profile. Frexalimab inhibits the binding between CD40 and CD40L to modulate immune response. Frexalimab is likely to help prevent the process of β-cell destruction. Frexalimab is proming for multiple sclerosis, lupus erythematosus, Sj gren’s syndrome and type I diabetes research.

For research use only. We do not sell to patients.

  • Purity: 99.00%
  • CAS No.: 2515463-86-0
  • Molecular Weight:145.698 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Frexalimab
  • Experimental Validation Results for Frexalimab
  • Experimental Validation Results for Frexalimab
  • Experimental Validation Results for Frexalimab
  • Frexalimab Chemical Structure
  • Experimental Validation Results for Frexalimab
  • Experimental Validation Results for Frexalimab
  • Experimental Validation Results for Frexalimab
  • Experimental Validation Results for Frexalimab
  • Frexalimab Chemical Structure
    Frexalimab Chemical Structure
CAS No.: 2515463-86-0
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometric analysis of 1X10EC6 500 ng/mL anti-CD3 stimulated Jurkat cells(24h) with Frexalimab (HY-P99625, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized Human CD40 Ligand/TNFSF5 Protein (His Tag) can bind Frexalimab. The EC50 for this effect is 2.43 ng/mL.

  • 1/16

    Loaded Frexalimab on AHC2 biosensor, can bind CD40L/CD154/TRAP Protein, Human (HEK293, Tag free, HY-P70609) with an affinity constant of 4.117E-10 M as determined in BLI assay.

  • Frexalimab Chemical Structure
    1/16
  • Frexalimab
  • Flow cytometric analysis of 1X10EC6 500 ng/mL anti-CD3 stimulated Jurkat cells(24h) with Frexalimab (HY-P99625, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized Human CD40 Ligand/TNFSF5 Protein (His Tag) can bind Frexalimab. The EC50 for this effect is 2.43 ng/mL.
  • Loaded Frexalimab on AHC2 biosensor, can bind CD40L/CD154/TRAP Protein, Human (HEK293, Tag free, HY-P70609) with an affinity constant of 4.117E-10 M as determined in BLI assay.