2. Immunology/Inflammation
  3. CD47
  4. ZL-1201

ZL-1201 is a recombinant humanized monoclonal anti-CD47 IgG4 antibody. ZL-1201 disrupt the CD47-SIRPα interaction. ZL-1201 modulates the tumor microenvironment. ZL-1201 promotes tumor-associated macrophage phagocytic activity. ZL-1201 substantially enhances phagocytosis by M2 macrophages, but not by M1 macrophages. ZL-1201 in combination with both mAb and chemotherapy achieves the maximal antitumor effects in a variety of solid tumor models. ZL-1201 can be used in the study of lymphoma, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, and gastric cancer.

For research use only. We do not sell to patients.

ZL-1201

ZL-1201 Chemical Structure

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ZL-1201 Related Antibodies

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Description

ZL-1201 is a recombinant humanized monoclonal anti-CD47 IgG4 antibody. ZL-1201 disrupt the CD47-SIRPα interaction. ZL-1201 modulates the tumor microenvironment. ZL-1201 promotes tumor-associated macrophage phagocytic activity. ZL-1201 substantially enhances phagocytosis by M2 macrophages, but not by M1 macrophages. ZL-1201 in combination with both mAb and chemotherapy achieves the maximal antitumor effects in a variety of solid tumor models. ZL-1201 can be used in the study of lymphoma, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, and gastric cancer[1].

Species Reactivity

Human
IC50 & Target

CD47
In Vitro

ZL-1201 (15 min) binds to CD47 on Jurkat cells[1].
ZL-1201 (10 μg/mL; 30 min) when combined with Trastuzumab (HY-P9907), Cetuximab (HY-P9905), or Rituximab (HY-P9913) significantly increases phagocytosis index compared to single agents or isotype control[1].
ZL-1201 (2 h) does not induce hemagglutination in whole blood[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZL-1201 Related Antibodies
In Vivo

ZL-1201 (10 mg/kg; i.p.; twice per week; 3–12 weeks) enhances antitumor efficacy in BALB/c nude mice with lymphoma, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, and gastric cancer xenografts (with a TGI of >80% in Raji lymphoma xenografts)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice[1]
Dosage: 10 mg/kg
Administration: i.p.; twice per week; 3–12 weeks
Result: Achieved >80% tumor growth inhibition (TGI) in Raji lymphoma xenografts; showed limited TGI (<50%) alone in solid tumor xenografts; significantly inhibited tumor growth when combined with therapeutic mAbs and chemotherapy, with triple combinations achieving maximal antitumor efficacy; increased intratumoral M1 macrophages, decreased M2 macrophages, and modulated cytokine release (increased TNFα/MCSF, decreased IL4) in the SKOV3 model
Clinical Trial
Gene ID

961  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZL-1201 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZL-1201ZL1201ZL 1201CD47Cluster of Differentiation 47MER6OA3CD47-SIRPα interactionM2 macrophagemonocyte-derived macrophagesSIRPαxenograft studiestumor modelsantitumor immunityJurkat cellstumor microenvironmentInhibitorinhibitorinhibit

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