CD47 - CD47 molecule Gene

Also Known as IAP; OA3; MER6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 961

About CD47

Cytogenetic location: 3q13.12 Genomic coordinates (GRCh38): 3:108,043,091-108,091,031 (from NCBI)

This gene has 6 transcripts (splice variants) and 125 orthologues. Ubiquitous expression in lung (RPKM 24.2), brain (RPKM 20.9) and 24 other tissues.

Summary

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

CD47 Products (3)

mRNA	Protein	Name
NM_001382306.1	NP_001369235.1	leukocyte surface antigen CD47 isoform 3 precursor
NM_001777.4	NP_001768.1	leukocyte surface antigen CD47 isoform 1 precursor
NM_198793.3	NP_942088.1	leukocyte surface antigen CD47 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell-cell adhesion mediator activity	IPI IPI: Inferred from physical interaction	11509594	GOA
enables fibrinogen binding	IDA IDA: Inferred from direct assay	22079249	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8550562	GOA
enables thrombospondin receptor activity	IDA IDA: Inferred from direct assay	8550562	GOA
enables thrombospondin receptor activity	IPI IPI: Inferred from physical interaction	15700281	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ATP export	IDA IDA: Inferred from direct assay	24022490	GOA
involved in cellular response to interleukin-12	IMP IMP: Inferred from mutant phenotype	11509594	GOA
involved in positive regulation of T cell activation	IDA IDA: Inferred from direct assay	15383453	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15383453	GOA
involved in positive regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	15383453	GOA
involved in regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	11509594	GOA
involved in regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	11509594	GOA
involved in regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	11509594	GOA
involved in regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	11509594	GOA
involved in regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	11509594	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	11509594	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD47 Protein Structure

V-set_CD47

CD47

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
leukocyte surface antigen CD47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

CD47 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD47	Q08722	SYNE4	Homo sapiens	Q8N205	Validated Y2H	25416956
Intra	CD47	Q08722	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD47 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7335	CD47 Protein, Human (HEK293, Fc)	Q08722-1 (Q19-P139)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7336	CD47 Protein, Human (HEK293, His)	Q08722-1/NP_942088.1 (Q19-P139)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72359	CD47 Protein, Human (Biotinylated, HEK293, Avi-His)	Q08722-1 (Q19-P139)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P72917	CD47 Protein, Human (HEK293)	Q08722-1/NP_942088.1 (Q19-P139)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78095	CD47 Protein, Human (Biotinylated, HEK293, His-Avi)	Q08722-1 (Q19-P139)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78561	CD47 Protein, Human (Biotinylated, HEK293, mFc-Avi)	Q08722-1 (Q19-P139)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78908	CD47 Protein, Human (Biotinylated, HEK293, hFc-Avi)	Q08722-1 (Q19-P139)	≥ 95%, as determined by reducing SDS-PAGE.

CD47 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80065	CD47 Antibody (YA531)	IHC-P	Human
HY-P84512	CD47 Antibody (YA4209)	WB, IHC-P, FC, ELISA	Human
HY-P84512A	CD47 Antibody (YA4209)(PBS only)	WB, IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Hereditary Spherocytosis	Congenital Spherocytic Hemolytic Anemia Spherocytic Anemia Congenital Spherocytosis Spherocytosis, Type 1 Minkowski Chauffard Syndrome Hs Minkowski-Chauffard Disease Minkowski-Chauffard Syndrome Spherocytosis Hereditary Spherocytosis, Hereditary Anemia, Hereditary Spherocytic Hemolytic
Glanzmann Thrombasthenia 1	Glanzmann Thrombasthenia Thrombasthenia Of Glanzmann And Naegeli Glanzmann'S Thrombasthenia Bdplt2 Platelet Glycoprotein Iib-Iiia Deficiency Deficiency Of Platelet Fibrinogen Receptor GT1 Gt Platelet Fibrinogen Receptor Deficiency Glycoprotein Complex Iib-Iiia Deficiency Deficiency Of Glycoprotein Complex Iib-Iiia Glycoprotein Iib/Iiia Defect Glanzmann Thrombasthenia, Type A Thrombasthenia Bleeding Disorder, Platelet-Type, 2 Gp Iib-Iiia Complex Deficiency Deficiency Of Gp Iib-Iiia Complex Platelet-Type Bleeding Disorder 2 Thrombocytasthenia Deficiency Of Gp 2b 3a Complex Diacyclothrombopathia 2b 3a Glanzmann Thrombasthenia Type A Platelet Fibrinogen Receptor, Deficiency Of Platelet Glycoprotein 2b 3a Deficiency Glanzmann Disease Glanzmann-Naegeli Disorder Hereditary Hemorrhagic Thrombasthenia Hereditary Thrombasthenia Bleeding Disorder Platelet-Type 2
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Congenital Dyserythropoietic Anemia	Congenital Dyshaematopoietic Anaemia Dyserythropoietic Anemia, Congenital Cda Anemia, Dyserythropoietic, Congenital Anemia Dyserythropoietic Congenital Cda - [Congenital Dyserythropoietic Anaemia] Dyserythropoietic Dyshaematopoietic Congenital Anaemia Dyshaematopoietic Anaemia Dyserythropoietic Anaemia
Hemolytic Disease Of Fetus And Newborn, Rh-Induced	Rh Deficiency Syndrome Rh Disease HDFNRH Rh Fetomaternal Incompatibility Rh-Null Syndrome
Contagious Pustular Dermatitis	Ecthyma, Contagious Orf Ecthyma Contagiosum Scabby Mouth Sheep Pox Thistle Disease Contagious Pustular Dermatosis
Tenosynovial Giant Cell Tumor	Fibrous Histiocytoma Of Tendon Sheath Giant Cell Tumor Of Tendon Sheath Giant Cell Tumor Of Tenosynovium Giant Cell Tumour Of Tendon Sheath Giant Cell Tumour Of Tenosynovium Tenosynovial Giant Cell Tumour Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Pigmented Villonodular Synovitis Tgct Tsgct
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Refractory Plasma Cell Neoplasm
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (20)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99029	Magrolimab	Inhibitor	99.92%	Phase 3
HY-P990954	Amulirafusp alfa		99.89%	Phase 3
HY-P991693	Ipsoprubart	Inhibitor	97%	Phase 3
HY-P99026	Lemzoparlimab	Inhibitor	99.31%	Phase 2
HY-P99950	Evorpacept	Inhibitor	99.75%	Phase 2
HY-P99777	Ontorpacept	Inhibitor	99.57%	Phase 2
HY-P99706	Ligufalimab	Inhibitor	98.81%	Phase 2
HY-P990707	Maplirpacept		97.73%	Phase 2
HY-P991016	Peluntamig		99.9%	Phase 2
HY-P991027	Spevatamig		≥99.0%	Phase 2
HY-P991561	AO-176	Inhibitor	/	Phase 2
HY-P99533	Urabrelimab	Inhibitor	99.487%	Phase 1
HY-P990033	Anzurstobart	Inhibitor	98.53%	Phase 1
HY-P99172	CC-90002	Inhibitor	97.97%	Phase 1
HY-P990694	Zeripatamig	Inhibitor	≥99.0%	Phase 1
HY-P991057	STI-6643	Inhibitor	99.62%	Phase 1
HY-P991062	Gentulizumab	Inhibitor	97.02%	Phase 1
HY-P991927	ZL-1201	Inhibitor	/	Phase 1
HY-P991560	TQB-2928	Inhibitor	/	Phase 1
HY-P991366	IBI-397	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16438	RRx-001	Inhibitor	99.79%	Yes
HY-P0144	Thrombospondin-1 (1016-1023) (human, bovine, mouse)	Inhibitor	98.75%	Unkown
HY-136780	SEN177		98.76%	Unkown
HY-143224B	NCGC00138783 TFA	Inhibitor	99.38%	Unkown
HY-P10420	RS17	Inhibitor	99.84%	Unkown
HY-P11205A	Cys-PKHB1 TFA	Activator	99.43%	Unkown
HY-115983	DMUP	Inhibitor	98.0%	Unkown
HY-RS02250	CD47 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-P11097	Pep-20	Inhibitor	99.86%	Unkown
HY-151132	Glutaminyl cyclases-IN-1	Inhibitor	98.21%	Unkown
HY-143224	NCGC00138783	Inhibitor	/	Unkown
HY-P10813	ZLIRTLHEWY	Inhibitor	99.41%	Unkown
HY-181797	CL121	Inhibitor	/	Unkown
HY-143224A	NCGC00138783 free base	Inhibitor	/	Unkown
HY-P11205	Cys-PKHB1	Activator	/	Unkown
HY-P10371	PKHB1	Agonist	99.84%	Unkown
HY-143225	NCGC00538431	Inhibitor	/	Unkown
HY-P3968	Thrombospondin-1 (1016-1021) (human, bovine, mouse)		/	Unkown

Inhibitory Antibodies (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990132	Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410)	Inhibitor	99.57%	Unkown
HY-P99175	KWAR 23	Inhibitor	99.24%	Unkown
HY-P990131	Anti-Mouse CD47/IAP Antibody (MIAP301)	Inhibitor	95.00%	Unkown
HY-P990858	Anti-CD47 Antibody (B6.H12)	Inhibitor	96.06%	Unkown
HY-P990555	BI-765063	Inhibitor	97.89%	Unkown
HY-P99903	Simridarlimab	Inhibitor	99.81%	Unkown
HY-P991023	Safimestomig	Inhibitor	≥99.0%	Unkown
HY-P990723	Timdarpacept	Inhibitor	99.95%	Unkown
HY-P991004	Itanistomig		95.84%	Unkown
HY-P990899	Amostomig		97.931%	Unkown
HY-P992176	ADU-1805	Inhibitor	/	Unkown
HY-P992320	BAT-6004	Inhibitor	/	Unkown
HY-P991755	Anti-Rat CD47 Antibody (OX-101)	Inhibitor	/	Unkown
HY-P992203	Anti-CD172a Antibody (3F9)		/	Unkown
HY-P991925	SHR-1603	Inhibitor	/	Unkown
HY-P991367	ES004	Inhibitor	/	Unkown
HY-P992346	DS-1103a	Inhibitor	/	Unkown
HY-P991926	VxP037	Inhibitor	/	Unkown
HY-P991923	Anti-CD47 Antibody (1F80)		/	Unkown
HY-P991924	CO-1	Inhibitor	/	Unkown
HY-P992158	VBI-009		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CD47	VGNC	VGNC:60628
Bos taurus	CD47	VGNC	VGNC:27035
Mus musculus	CD47	MGD	MGI:96617
Macaca mulatta	CD47	VGNC	VGNC:70767
Rattus norvegicus	CD47	RGD	RGD:2308
Canis familiaris	CD47	VGNC	VGNC:38960
Others	CD47	NCBI