2. Immunology/Inflammation
  3. CD47
  4. VBI-009

VBI-009 is a CD47 and B7-H3 (CD276) bispecific antibody. VBI-009 blocks CD47-SIRPα 'don't eat me' signals and restricts activity to CD47+/B7-H3+ cells. VBI-009 induces antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC) in CD47+/B7-H3+ tumor cells. VBI-009 inhibits tumor growth in CD47+/B7-H3+ lung cancer xenograft models. VBI-009 can be used for the research of lung cancer.

For research use only. We do not sell to patients.

VBI-009

VBI-009 Chemical Structure

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Description

VBI-009 is a CD47 and B7-H3 (CD276) bispecific antibody. VBI-009 blocks CD47-SIRPα 'don't eat me' signals and restricts activity to CD47+/B7-H3+ cells. VBI-009 induces antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC) in CD47+/B7-H3+ tumor cells. VBI-009 inhibits tumor growth in CD47+/B7-H3+ lung cancer xenograft models. VBI-009 can be used for the research of lung cancer[1].

Species Reactivity

Human
In Vitro

VBI-009 selectively binds to CD47+/B7-H3+ tumor cells, shows minimal to no binding to B7-H3-negative cells, and does not bind significantly to human red blood cells[1].
VBI-009 potently blocks the CD47/SIRPα axis on CD47+/B7-H3+ tumor cells, with minimal to no activity on B7-H3-negative cells[1].
VBI-009 drives potent antibody-dependent cellular phagocytosis of CD47+/B7-H3+ tumor cells, with minimal to no activity on B7-H3-negative cells[1].
VBI-009 drives potent antibody-dependent cellular cytotoxicity of CD47+/B7-H3+ tumor cells, with minimal to no activity on B7-H3-negative cells[1].
VBI-009 does not induce hemagglutination of human red blood cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VBI-009 Related Antibodies
In Vivo

BI-009 inhibits tumor growth in CD47+/B7-H3+ lung cancer xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID

80381  [NCBI] & 16423  [NCBI]

Accession

Q5ZPR3 & Q61735-1
Target

B7-H3/CD276 & CD47
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VBI-009 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VBI-009VBI009VBI 009CD47Cluster of Differentiation 47MER6OA3lung cancer xenograft modelsB7-H3lung cancerred blood cellantibody-dependent cellular cytotoxicitytumor cellsSIRPαantibody-dependent cellular phagocytosisInhibitorinhibitorinhibit

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VBI-009
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