2. Inhibitory Antibodies
  3. Ontorpacept

Ontorpacept  (Synonyms: TTI-621)

Cat. No.: HY-P99777 Purity: 99.57%
COA

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Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity.

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Ontorpacept Chemical Structure

Ontorpacept Chemical Structure

CAS No. : 2131089-46-6

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Description

Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity[1].

In Vitro

Ontorpacept (0.001-1000 nmol/L; 2 h) dose-dependently increases macrophage phagocytosis of tumor cells with an average EC50 of 10 nmol/L in primary samples from patients with AML, MDS, multiple myeloma, B-ALL, and T-ALL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ontorpacept Related Antibodies
In Vivo

Ontorpacept (8 mg/kg; i.p., 3 times a week for 4 weeks) shows antitumor effects in NOD. SCID mice with AML xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD.SCID mice with AML cell transplants[1]
Dosage: 8 mg/kg
Administration: Intraperitoneal injection; 8 mg/kg, 3 times a week for 4 weeks
Result: Significantly reduced the tumor growth in bone marrow and spleen.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ontorpacept]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.57%

COA (231 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ontorpacept2131089-46-6TTI-621TTI621TTI 621Othersfusion proteinSIRPαIgG1phagocytosismacrophagecheckpoint inhibitorInhibitorinhibitorinhibit

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