2. Apoptosis
  3. Apoptosis
  4. DMUP

DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity.

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DMUP Chemical Structure

DMUP Chemical Structure

CAS No. : 2364350-07-0

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DMUP Related Antibodies

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Description

DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity[1].

In Vitro

DMUP (72 h) shows antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 µM for A549, A549/DDP, PANC-1, HepG2 cells, respectively[1].
DMUP (5 µM, 24 h) arrests the cell cycle in S phase in A549 cells[1].
DMUP (5 µM, 48 h) induces apoptosis in A549 cells[1].
DMUP (5 µM, 24 h) decreases the expression of CD47 and SIRPα protein[1].
DMUP (5 µM, 4 h) increases the macrophage phagocytosis in A549-GFP cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DMUP Related Antibodies

Cell Proliferation Assay[1]

Cell Line: A549, A549/DDP, PANC-1, HepG2 cells
Concentration: 0-64 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 µM for A549, A549/DDP, PANC-1, HepG2 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Arrested the cell cycle in the S phase.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 5 µM
Incubation Time: 48 h
Result: Induced cell apoptosis.

Western Blot Analysis[1]

Cell Line: A549, THP-1 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Decreased the expression of CD47 and SIRPα protein.
In Vivo

DMUP (10 mg/kg, i.v., every other day for 17 day) shows antitumor activity[1].
DMUP (5, 10, 20, 40 mg/kg, i.v.,every two days for 18 days) shows no toxicity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[1]
Dosage: 5, 10, 20, 40 mg/kg
Administration: i.v., every two days, 18 days
Result: Showed low toxicity with LD50 of greater than 20 mg/kg.
Animal Model: A549 xenograft BALB/c nude mice[1]
Dosage: 10 mg/kg
Administration: i.v., every other day, 17 day
Result: Showed antitumor activity.
Molecular Weight

766.44

Formula

C24H24Cl2N2O10Pt
CAS No.
SMILES

O=C1OC2=C(C(C)=C1)C=CC(OCC([O-][Pt+4]([Cl-])([O-]C(COC3=CC(OC(C=C4C)=O)=C4C=C3)=O)([NH3])([NH3])[Cl-])=O)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DMUP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMUP2364350-07-0ApoptosisPlatinum(IV)peripheral blood mononuclear cells (PBMCs)macrophage phagocytosisA549 cellsS phaseapoptosisantitumorInhibitorinhibitorinhibit

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