1. Apoptosis
  2. Apoptosis
  3. DMUP

DMUP 

Cat. No.: HY-115983
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DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity.

For research use only. We do not sell to patients.

DMUP Chemical Structure

DMUP Chemical Structure

CAS No. : 2364350-07-0

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Description

DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity[1].

In Vitro

DMUP (72 h) shows antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 µM for A549, A549/DDP, PANC-1, HepG2 cells, respectively[1].
DMUP (5 µM, 24 h) arrests the cell cycle in S phase in A549 cells[1].
DMUP (5 µM, 48 h) induces apoptosis in A549 cells[1].
DMUP (5 µM, 24 h) decreases the expression of CD47 and SIRPα protein[1].
DMUP (5 µM, 4 h) increases the macrophage phagocytosis in A549-GFP cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: A549, A549/DDP, PANC-1, HepG2 cells
Concentration: 0-64 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 µM for A549, A549/DDP, PANC-1, HepG2 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Arrested the cell cycle in the S phase.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 5 µM
Incubation Time: 48 h
Result: Induced cell apoptosis.

Western Blot Analysis[1]

Cell Line: A549, THP-1 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Decreased the expression of CD47 and SIRPα protein.
In Vivo

DMUP (10 mg/kg, i.v., every other day for 17 day) shows antitumor activity[1].
DMUP (5, 10, 20, 40 mg/kg, i.v.,every two days for 18 days) shows no toxicity in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[1]
Dosage: 5, 10, 20, 40 mg/kg
Administration: i.v., every two days, 18 days
Result: Showed low toxicity with LD50 of greater than 20 mg/kg.
Animal Model: A549 xenograft BALB/c nude mice[1]
Dosage: 10 mg/kg
Administration: i.v., every other day, 17 day
Result: Showed antitumor activity.
Molecular Weight

766.44

Formula

C24H24Cl2N2O10Pt

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